|
NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.49 [2011] >
IJEB Vol.49(07) [July 2011] >
| Title: | Effect of Ayurvedic mercury preparation Makaradhwaja on geriatric canine–A preliminary study |
| Authors: | Sinyorita, S
Ghosh, C K
Chakrabarti, A
Auddy, B
Ghosh, Runa
Debnath, P K |
| Keywords: | Ayurvedic mercury preparation
Geriatric dog
Makaradhwaja |
| Issue Date: | Jul-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Makaradhwaja, an alchemical
Ayurvedic mercury preparation is used as stimulant and vitalizer. Towards
veterinary practices, the acceptability, tolerability and toxicity studies were
undertaken in geriatric pet dogs aged more than 10 years irrespective of breed
and sex for future use. Makaradhwaja
(2.5 mg/kg) was used with honey once daily for 30 days. Before and after
treatment, blood was collected for hematological studies as well as liver,
kidney function and anti-oxidant activity. In control group, honey itself
showed no appreciable change whereas, Makaradhwaja
lowered neutrophil and total leucocyte count. Serum cholesterol, urea, glucose,
alanine amino transferase, aspartate amino transferase, sodium, phosphorus and
calcium were decreased. Haemoglobin and serum creatinine were significantly
increased. There was appreciable physical, behavioral and body weight change
including quality of life. The dose was used in replication of human dose (125
mg/50kg). Anti-oxidant study showed significant increase of lipid per oxidation
in experimental group while the values of ABTS radical cation decolorisation assay although decreased but
did not show any significant changes. Decrease of serum urea and increase of
serum creatinine could not be explained on single dose response. Different dose
study could only explain the optimum dose to be required in canine practices. |
| Page(s): | 534-539 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.49(07) [July 2011]
|
|
