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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.49 [2011] >
IJEB Vol.49(07) [July 2011] >
| Title: | Antiulcer activity of Andrographis paniculata (Burm.f.) Wall. against cysteamine-induced duodenal ulcer in rats |
| Authors: | Saranya, P
Geetha, A |
| Keywords: | Andrographis paniculata
Basolateral membrane
Brushborder membrane
Cysteamine
Duodenal ulcer
Mucin |
| Issue Date: | Jul-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Antiulcer activity of Andrographis paniculata was evaluated by cysteamine induced
duodenal ulcer model in rats. Male albino Wistar rats were pre-administered
with 200 mg/kg body wt. of hydroalcoholic extact of Andrographis paniculata (HAEAP) orally, for 30 days prior to i.p.
administration of 420 mg/kg body wt. of cysteamine as a single dose. Rats
pre-administered with 30 mg/kg body wt. of ranitidine served as standard drug.
Ulcer index, thiobarbituric acid reactive substances, mucin, glutathione
peroxidase and myeloperoxidase activities, reduced glutathione/oxidized
glutathione (GSH/GSSG) ratio, glycoproteins and membrane bound enzyme
activities were measured in duodenum of experimental animals. The ulcer score
and myeloperoxidase activity were significantly minimized in rats treated with
HAEAP. Mucin content was found to be preserved in rats treated with the
extract. GSH/GSSG ratio and glutathione peroxidase activities were found to be
maintained by the HAEAP. Level of lipid peroxidation products was found to be
significantly low in HAEAP treated rats compared to ulcer control rats. The
basolateral and brush border membrane bound enzyme activities which were
depleted significantly in ulcer control rats were found to be maintained in
rats pre-treated with the extract. The ulcer preventing effect was comparable
to that of ranitidine treated rats. Level of glycoproteins was also found to be
preserved in rats treated with the extract. The normal rats treated with the
HAEAP did not show any abnormal alterations in the parameters studied.
Histopathological observations also showed the ulcer preventing effect of the
HAEAP. It is suggested that the ulcer preventing effect may be due to its mucin
preserving and antioxidant nature. |
| Page(s): | 525-533 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.49(07) [July 2011]
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