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|Title:||Effect of silymarin on curcumin-induced mortality in zebrafish (<i>Danio rerio</i>) embryos and larvae|
|Abstract:||In presence of 7.5 <img src='/image/spc_char/micro.gif' border=0> M of curcumin, no embryos or larva of zebrafish survived 3 days of incubation; however, co-incubation with 144 <img src='/image/spc_char/micro.gif' border=0> g/ml silymarin increased the survival rates of curcumin-treated embryos and larvae to about 70%. Moreover, in presence of 12.5 <img src='/image/spc_char/micro.gif' border=0>M curcumin, all embryos died after 2 days of incubation; however, co-treatment with 144 <img src='/image/spc_char/micro.gif' border=0>g/ml silymarin increased the survival rates of curcumin-treated embryos and larvae up to 60 and 50%, respectively. This protective effect was not found in the other phenolic compounds viz., ferulic acid, naringin, or crocin, tested. Finally, using a fluorescence microscope, accumulation of less curcumin has observed in the edema sac area of the larvae co-treated with curcumin and silymarin than in the larvae treated with curcumin only. The result suggests that the protective effects of silymarin may be due to a decreased accumulation of curcumin in the fish body.|
|ISSN:||0975-1009 (Online); 0019-5189 (Print)|
|Appears in Collections:||IJEB Vol.49(07) [July 2011]|
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