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Indian Journal of Biochemistry and Biophysics (IJBB) >
IJBB Vol.48 [2011] >
IJBB Vol.48(3) [June 2011] >
| Title: | Growth inhibition of struvite crystals by the aqueous root extract of Rotula aquatica |
| Authors: | Chauhan, C K
Joshi, M J
Vaidya, A D B |
| Keywords: | Bio-crystallization
Gel growth
Kidney stone
Rotula aquatica
Struvite |
| Issue Date: | Jun-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Formation of urinary stone is a serious and debilitating problem throughout
the world. In the present study, the inhibitory effect of aqueous extract of
root of Rotula aquatica was investigated against
struvite crystals (one of the components of urinary stone) grown in
vitro using single diffusion gel growth technique. For setting the gel,
sodium metasilicate solution (specific gravity 1.05) and 0.5 M aqueous solution
of ammonium dihydrogen phosphate were mixed, so that the pH of the mixture
could be set at 7.0. Equal amounts of supernatant solution of magnesium acetate
(1.0 M) prepared with 0.0%, 0.5% and 1% concentrations of the extract were
gently poured on the set gels. It was observed that the number, dimension,
total mass, total volume, growth rate and depth of growth of struvite crystals
decreased with the increasing extract concentrations in the supernatant
solutions. The enhancement of dissolution rate and fragmentation of struvite
crystals suggested potential application of the extract for inhibition
of struvite type urinary stone |
| Page(s): | 202-207 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0959 (Online); 0301-1208 (Print) |
| Source: | IJBB Vol.48(3) [June 2011]
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