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Title: <img src='/image/spc_char/alpha.gif' border=0> -Tocopherol ameliorates cypermethrin-induced toxicity and oxidative stress in the nematode <i>Caenorhabdtis elegans</i>
Authors: Shashikumar, Shivaiah
Rajini, P S
Keywords: Cypermethrin
<i>Caenorhabditis elegans</i>
Oxidative stress
<img src='/image/spc_char/alpha.gif' border=0> -Tocopherol
Issue Date: Jun-2011
Publisher: NISCAIR-CSIR, India
Abstract: Oxidative stress and other effects induced by cypermethrin (CYP, 15 mM) and their amelioration by <img src='/image/spc_char/alpha.gif' border=0>-tocopherol (400 <img src='/image/spc_char/micro.gif' border=0>M) was studied in the nematode <i>Caenorhabditis elegans</i>. The worms exposed for 4 h to CYP showed increased  levels of reactive oxygen species (46%), H<sub>2</sub>O<sub>2 </sub>(37%) and protein carbonyls (29%), accompanied by decreased lifespan and brood size. However,  exposure to both CYP and a-tocopherol resulted in diminution of above alterations with the worms exhibiting relatively lower levels of ROS (30%), H<sub>2</sub>O<sub>2</sub> (15%), protein carbonyls (14%), altered antioxidant enzyme activities and normal lifespan and brood size. The results suggest that CYP induces oxidative stress in <i>C. elegans</i> and the strategy of intervention with <img src='/image/spc_char/alpha.gif' border=0>-tocopherol could be exploited to offset this induced oxidative stress.
Description: 191-196
ISSN: 0975-0959 (Online); 0301-1208 (Print)
Appears in Collections:IJBB Vol.48(3) [June 2011]

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