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NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Biochemistry and Biophysics (IJBB) >
IJBB Vol.48 [2011] >
IJBB Vol.48(3) [June 2011] >
| Title: |  -Tocopherol ameliorates cypermethrin-induced toxicity and oxidative stress in the nematode Caenorhabdtis elegans |
| Authors: | Shashikumar, Shivaiah
Rajini, P S |
| Keywords: | Cypermethrin
Caenorhabditis elegans
Oxidative stress
-Tocopherol |
| Issue Date: | Jun-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Oxidative stress and
other effects induced by cypermethrin (CYP, 15 mM) and their amelioration by -tocopherol
(400  M) was studied in the nematode Caenorhabditis
elegans. The worms exposed for 4 h to CYP showed increased levels of reactive oxygen species (46%), H2O2
(37%) and protein carbonyls (29%), accompanied by decreased lifespan and
brood size. However, exposure to both
CYP and a-tocopherol resulted in diminution of
above alterations with the worms exhibiting relatively lower levels of ROS
(30%), H2O2 (15%), protein carbonyls (14%), altered
antioxidant enzyme activities and normal lifespan and brood size. The results
suggest that CYP induces oxidative stress in C. elegans and the strategy
of intervention with -tocopherol
could be exploited to offset this induced oxidative stress. |
| Page(s): | 191-196 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0959 (Online); 0301-1208 (Print) |
| Source: | IJBB Vol.48(3) [June 2011]
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