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IJC-B Vol.50B(06) [June 2011] >

Title: Synthesis and characterization of some novel isoxazolines and pyrazolines as potent antimicrobial agents
Authors: Badadhe, P V
Chavan, N M
Mandhane, P G
Joshi, R S
Nagargoje, D R
Gill, C H
Keywords: Isoxazolines
Antimicrobial activity
Issue Date: Jun-2011
Publisher: NISCAIR-CSIR, India
Abstract: The title compounds 4a-h and 5a-h, have been prepared starting from chalcones 3a-h having 5-chlorothiophene moiety. Chalcones 3a-h react with hydroxylamine hydrochloride in presence of alkali to afford isoxazolines 4a-h. Further 3a-h react with hydrazine hydrate in presence of glacial acetic acid to give pyrazolines 5a-h. The structures of newly synthesized compounds have been confirmed by elemental analysis as well as IR, 1H NMR and mass spectral data. The newly synthesized compounds have been screened for their antimicrobial activity. Some of the compounds show moderate antimicrobial activity as compared to the known reference drugs Gentamycin, Cefixime and Ketoconazole.
Page(s): 879-884
CC License:  CC Attribution-Noncommercial-No Derivative Works 2.5 India
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.50B(06) [June 2011]

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