NISCAIR Online Periodicals Repository

NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR)  >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.50B [2011] >
IJC-B Vol.50B(06) [June 2011] >


Title: Exploring structure indenture of some aminopyrazolopyridine ureas as potent VEGFR/PDGFR multitargeted kinase inhibitors: A QSAR approach
Authors: Vyas, Vivek K
Joshi, Garvita
Namdeo, Basant
Gupta, Arpit
Keywords: QSAR
Angiogenesis
VEGFR
KDR inhibitor
Aminopyrazolopyridine ureas
Issue Date: Jun-2011
Publisher: NISCAIR-CSIR, India
Abstract: The feasibility that inhibition of kinase domain receptor (KDR), vascular endothelial growth factor receptor (VEGFR) and platelet derived growth factor receptor (PDGFR) kinases is a promising strategy in anticancer research, which reduces tumor growth by limiting the formation of new capillaries from existing vasculature In this work, quantitative structure activity relationship (QSAR) study is reported employing Hansch analysis, Fujita-ban analysis and molecular modeling study on a series of 3-aminopyrazolopyridine ureas with KDR and other kinase inhibitors. The internal (correlation coefficient r2) consistency of the QSAR model for Fujita-ban and Hansch analysis is 0.856 and 0.806 respectively. The model has been also tested successfully for internal (q2 >0.88) and external (predictive r2 > 0.72) validation criteria. Thus, this validated model brings important structural insight to aid the design of novel antitumor agents. The studies demonstrate that steric, hydrophobic and electronic properties play an important role in inhibition of KDR.
Page(s): 858-867
CC License:  CC Attribution-Noncommercial-No Derivative Works 2.5 India
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.50B(06) [June 2011]

Files in This Item:

File Description SizeFormat
IJCB 50B(6) 858-867.pdf127.07 kBAdobe PDFView/Open
 Current Page Visits: 939 
Recommend this item

 

National Knowledge Resources Consortium |  NISCAIR Website |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2012 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 576541 since 06-Feb-2009  Last updated on 26-Aug-2014Webmaster: nopr@niscair.res.in