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http://nopr.niscair.res.in/handle/123456789/11910| Title: | Synthesis and regiospecific methylation of new benzimidazolyl β-ketosulfones and β-hydroxysulfones |
| Authors: | Kumar, N D Mahesh Dubey, P K |
| Keywords: | Regiospecific alkylation;Phase-transfer catalyst;2-Mercaptobenzimidazole |
| Issue Date: | Jun-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Condensation of 2-mercaptobenzimidazoles 1a-e with α-bromoacetylbenzene 2 resulting in benzimidazolyl β-ketosulfides 3a-e followed by oxidation with hydrogen peroxide giving β-ketosulfones 7a-e and subsequent reduction with sodium borohydride yielding β-hydroxysulfones 9a-e is described. Reaction of 3a, 8a, 7a and 9a with DMS in the presence of potassium carbonate as base and tetrabutylammonium bromide (TBAB) as phase transfer catalyst, results in the regiospecific N-methylation of the NH of benzimidazole moiety giving 11a, 10a, 13a and 12a respectively. |
| Page(s): | 829-834 |
| URI: | http://hdl.handle.net/123456789/11910 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Appears in Collections: | IJC-B Vol.50B(06) [June 2011] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 50B(6) 829-834.pdf | 86.12 kB | Adobe PDF | View/Open |
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