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Title: Stereoselective preparation of a key intermediate toward the synthesis of nelfinavir
Authors: Raghavan, Sadagopan
Kumar, Ch Naveen
Keywords: Nelfinavir
Pummerer reaction
Issue Date: Jun-2011
Publisher: NISCAIR-CSIR, India
Abstract: A stereoselective synthesis of an intermediate that can be elaborated into the potent HIV-protease inhibitor, nelfinavir, is described. The key step of the reaction sequence is the stereoselective preparation of a bromosulfonamide from an olefin using the sulfilimine moiety as an intramolecular nucleophile.
Description: 821-828
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.50B(06) [June 2011]

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