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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.49 [2011] >
IJEB Vol.49(06) [June 2011] >
| Title: | Anti-ulcerogenic and proton pump (H+, K+ ATPase) inhibitory activity of Kolaviron from Garcinia kola Heckel in rodents |
| Authors: | Onasanwo, Samuel A
Singh, Neetu
Olaleye, Samuel B
Palit, Gautam |
| Keywords: | Anti-secretory
Cyto-protection
Garcinia kola
H+
K+-ATPase
Kolaviron
Omeprazole
Peptic ulcer |
| Issue Date: | Jun-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Anti-ulcer
potential and proton pump inhibitory activity of kolaviron (KV) isolated from Garcinia kola Heckel has
been evaluated using different ulcer models. Cold-restraint (CRU), aspirin
(ASP), alcohol (AL), pyloric ligation (PL) induced gastric ulcer models were
used to assess anti-ulcerogenic activity
of KV in rats. Effects of KV on gastric juice for free and total acidity,
peptic activity and mucin secretion were also evaluated. The H+, K+-ATPase
activity was assayed in gastric microsomes, spectrophotometrically. Results of
this study showed that KV (200 mg/kg) reduced the incidence of ulcers in CRU
(69.0%), PL (67.6%), ASP (68.6%) and AL (51.5%). Reductions were also observed
in free acidity (32.6%), total
acidity (56.2%) and peptic
activity (35.4%) with increase
in mucin secretion by 40.1%. KV
inhibited the H+,K+-ATPase activity with IC50
of 43.8  g/ml compared with omeprazole with IC50 of 32.3 g/ml. KV
showed both cyto-protective and anti-secretory potentials against peptic
ulcer models, and a proton pump inhibitory activity. KV may emerge as a potent
anti-ulcer compound. |
| Page(s): | 461-468 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.49(06) [June 2011]
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