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NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
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Research Journals >
Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.49 [2011] >
IJEB Vol.49(06) [June 2011] >
| Title: | Hepatoprotective and antioxidant properties of Suaeda maritima (L.) Dumort ethanolic extract on concanavalin-A induced hepatotoxicity in rats |
| Authors: | Ravikumar, S
Gnanadesigan, M
Inbaneson, S Jacob
Kalaiarasi, A |
| Keywords: | Acute toxicity
Concanavalin-A
Hepatoprotective
Salt marsh
Suaeda maritima |
| Issue Date: | Jun-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Hepatoprotective and
antioxidant properties of Suaeda maritima
(L.) Dumort on
concanavalin-A induced stress in Wistar albino rats have been reported. Rats
were administered with ethanolic extract of Suaeda maritima at the
concentration of 75, 150 and 300 mg/kg of body wt. for 9 days and
concanavalin-A was administrated (iv) 12 mg/kg on 9th day. Rats in
concanavalin-A administered group showed elevated levels of AST, ALT, ALP and
bilurubin. Pretreatment of rats with ethanolic extract (300 mg/kg)
significantly reduced these serum parameters compared to concavalin-A
administered group. Histopathological examination of liver sections showed
that, normal liver architecture was disturbed by hepatotoxin intoxication. The
extract treated group and silymarin treated group retained the normal cell
architecture, although less visible changes were observed. Preliminary phytochemical
analysis showed the presence of triterpenioids and may be responsible for the
hepatoprotective activity. The LD50 was calculated as 3 g/kg of the
body weight. IC50 values of hydroxyl (52.21±1.32 g/ml) and nitric oxide
radicals (09.14±0.94 g/ml) scavenging results showed comparable activity with
vitamin-C. Results of this study may be useful for the development of herbal
medicine from Suaeda maritima for the
treatment of hepatitis. |
| Page(s): | 455-460 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.49(06) [June 2011]
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