|
NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.49 [2011] >
IJEB Vol.49(06) [June 2011] >
| Title: | Sub-chronic diclofenac sodium induced alterations of alkaline phosphatase activity in serum and skeletal muscle of mice |
| Authors: | Chouhan, Shalini
Sharma, Sushma |
| Keywords: | Alkaline phosphatase
Diclofenac
Gastrocnemius
Serum
Sub-chronic |
| Issue Date: | Jun-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | The present
study has been carried on changes in activity of alkaline phosphatase in serum
and gastrocnemius muscle of mice after sub-chronic use of diclofenac. Mice in experimental
group received diclofenac (10 mg/kg body wt /day) for 30 days while control
group received normal saline. Alkaline phosphatase was assayed in muscle and
serum and its activity was localized histochemically in muscle. Results showed
that diclofenac induced changes in specific activity of alkaline phosphatase at
different periods of treatment variably compared to control group. Specific
activity of alkaline phosphatase decreased significantly in gastrocnemius
initially (48.74%), increased thereafter (132.96%) and slight
decrease (13.97%) was noticed after 30 days. In serum, the specific activity of
alkaline phosphatase decreased slightly after 10 days (18.78%),
increased in the middle of the treatment period (132.04%) as well as showed
increase (109.09%) compared to control group after 30 days stage of investigation.
These findings were also confirmed by electrophoretic studies in muscle. |
| Page(s): | 446-454 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.49(06) [June 2011]
|
|
