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Title: Stem cell therapies for type 1 diabetes mellitus
Authors: Voltarelli, Júlio C
Couri, Carlos E B
Rodrigues, Maria C
Moraes, Daniela A
Stracieri, Ana-Beatriz P L
Pieroni, Fabiano
Navarro, George
Leal, Angela M O
Simões, Belinda P
Keywords: Diabetes mellitus;HSCT;Immunosupression;Stem cell
Issue Date: Jun-2011
Publisher: NISCAIR-CSIR, India
Abstract: The present review discusses the use of autologous hematopoietic stem cell transplantation (HSCT) for the treatment of diabetes mellitus type 1 (DM 1). It has been observed that high dose immunosuppression followed by HSCT shows better results among other immunotherapeutic treatments for the disease as the patients with adequate beta cell reserve achieve insulin independence. However, this response is not maintained and reoccurrence of the disease is major a major challenge to use HSCT in future to prevent or control relapse of DM 1.
Page(s): 395-400
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.49(06) [June 2011]

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