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Title: Synthesis, spectral characterization and DNA cleavage studies of Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and Hg(II) complexes with benzofuran-2-carbohydrazide schiff bases
Authors: Halli, M B
Patil, Vijayalaxmi B
Keywords: Coordination chemistry
Schiff bases
DNA cleavage
Issue Date: May-2011
Publisher: NISCAIR-CSIR, India
Abstract: New schiff bases have been synthesized from benzofuran-2-carbohydrazide and 1-naphthaldehyde [NMBC] or 6-methoxy-2-naphthaldehyde [MNMBC]. Complexes of the type MLX2, where M = Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and Hg(II), L = NMBC or MNMBC and X = Cl, have been synthesized and characterized on the basis of analytical data, IR, UV-vis, 1H NMR, DART-MS and ESR spectral data and magnetic studies. All the complexes are soluble in DMF and DMSO. The measured molar conductance values indicate that the complexes are non-electrolytic in nature. The DNA cleavage activities of the schiff bases and their Co(II), Ni(II) and Cu(II) complexes have been studied by agarose gel electrophoresis method. The Cu(II), Ni(II) and Co(II) complexes have also been studied for their plasmid (pBR322) DNA cleavage activity.
Description: 664-669
ISSN: 0975-0975(Online); 0376-4710(Print)
Appears in Collections:IJC-A Vol.50A(05) [May 2011]

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