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Indian Journal of Chemistry -Section A (IJC-A) >
IJC-A Vol.50A [2011] >
IJC-A Vol.50A(05) [May 2011] >
| Title: | Synthesis, spectral characterization and DNA cleavage studies of Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and Hg(II) complexes with benzofuran-2-carbohydrazide schiff bases |
| Authors: | Halli, M B
Patil, Vijayalaxmi B |
| Keywords: | Coordination chemistry
Benzofurans
Schiff bases
DNA cleavage
Copper
Nickel
Cobalt
Zinc
Cadmium
Mercury |
| Issue Date: | May-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | New schiff bases have been synthesized from
benzofuran-2-carbohydrazide and 1-naphthaldehyde [NMBC] or
6-methoxy-2-naphthaldehyde [MNMBC]. Complexes of the type MLX2,
where M = Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and Hg(II), L = NMBC or MNMBC
and X = Cl, have been synthesized and characterized on the basis of analytical
data, IR, UV-vis, 1H NMR, DART-MS and ESR spectral data and magnetic
studies. All the complexes are soluble in DMF and DMSO. The measured molar
conductance values indicate that the complexes are non-electrolytic in nature.
The DNA cleavage activities of the schiff bases and their Co(II), Ni(II) and
Cu(II) complexes have been studied by agarose gel electrophoresis method. The
Cu(II), Ni(II) and Co(II) complexes have also been studied for their plasmid
(pBR322) DNA cleavage activity. |
| Page(s): | 664-669 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0975(Online); 0376-4710(Print) |
| Source: | IJC-A Vol.50A(05) [May 2011]
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