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Title: Synthesis of oxadiazoles and pyrazolones as a antimycobacterial and antimicrobial agents
Authors: Thaker, K M
Ghetiya, R M
Tala, S D
Dodiya, B L
Joshi, K A
Dubal, K L
Joshi, H S
Keywords: Oxadiazoles
Antimycobacterial activity
Antimicrobial activity
Issue Date: May-2011
Publisher: NISCAIR-CSIR, India
Abstract: Heterosubstituted oxadiazoles and pyrazolones derivatives have been synthesized by reaction of 3,5-dichlorobenzo[b]­thiophene-2-carbohydrazide 1 and arylaldehydes in dioxane to afford (E)-N’-Arylmethylidene-3,5-dichlorobenzo[b]thiophene-2-carbohydrazides 2a-k. Compounds 2a-k on reaction with acetic anhydride give 5-(3,5-dichlorobenzo[b]thiophen-2-yl)-2-aryl-3-acetyl-(2H)1,3,4-oxadiazoles 3a-k. Furthermore, compound 1 on reaction with Ethyl (2E)-3-oxo-2-arylhydrazinylidene butanoate in presence of glacial acetic acid gives (4E)-2-[(3,5-dichloro­benzo[b]thiophen-2-yl)carbonyl]-5-methyl-4-arylhydrazinylidene-2,4-dihydro-3H-pyrazolone 4a-k. Their IR, 1H NMR, mass spectral data and elemental analysis are in accord with assigned structure. All the newly synthesized compounds have been screened for their antimicrobial activity and antitubercular activity.
Description: 738-744
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.50B(05) [May 2011]

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