NISCAIR Online Periodicals Repository

NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR)  >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.50B [2011] >
IJC-B Vol.50B(05) [May 2011] >


Title: Synthesis and evaluation of N-( -benzamido cinnamoyl) aryl hydrazone derivatives for anti-inflammatory and antioxidant activities
Authors: Rajitha, G
Saideepa, N
Praneetha, P
Keywords: Acylhydrazone
Hydrazone
Anti-inflammatory
Antioxidant activity
Issue Date: May-2011
Publisher: NISCAIR-CSIR, India
Abstract: A series of novel N-(-benzamido cinnamoyl) aryl hydrazone derivatives 3a-m have been synthesized and screened for their anti-inflammatory and antioxidant activities. These compounds have been synthesized by refluxing intermediate -benzamido-cinnamhydrazide with substituted benzaldehydes in the presence of a few drops of glacial acetic acid. The intermediate a-benzamido-cinnamhydrazide is prepared by stirring 4-benzyli­dene-2-phenyl oxazole-5-one with hydrazine hydrate in presence of absolute ethanol. The chemical structures of the compounds are established by IR, 1H NMR and mass spectral data. Of all the compounds screened, compound 3m N'-(5-bromo-4-hydroxy-3-methoxybenzylidene)-2-(benzamido)-3-phenyla­cry­lo­hydrazide shows anti-inflammatory activity (75%) which is equivalent to that produced by the same dose (100 mg/kg) of phenylbutazone (74%). Compound 3l N'-(4-hydroxy-3-methoxy benzylidene)-2-(benzamido)-3-phenyl acrylohydrazide, shows good anti-inflammatory and antioxidant activity.
Page(s): 729-733
CC License:  CC Attribution-Noncommercial-No Derivative Works 2.5 India
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.50B(05) [May 2011]

Files in This Item:

File Description SizeFormat
IJCB 50B(5) 729-733.pdf65.27 kBAdobe PDFView/Open
 Current Page Visits: 491 
Recommend this item

 

National Knowledge Resources Consortium |  NISCAIR Website |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2012 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 511363 since 06-Feb-2009  Last updated on 11-Apr-2014Webmaster: nopr@niscair.res.in