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Title: Synthesis and evaluation of N-(<img src='/image/spc_char/alpha.gif' border=0> -benzamido cinnamoyl) aryl hydrazone derivatives for anti-inflammatory and antioxidant activities
Authors: Rajitha, G
Saideepa, N
Praneetha, P
Keywords: Acylhydrazone
Antioxidant activity
Issue Date: May-2011
Publisher: NISCAIR-CSIR, India
Abstract: A series of novel N-(<img src='/image/spc_char/alpha.gif' border=0>-benzamido cinnamoyl) aryl hydrazone derivatives<b style=""> 3a-m </b>have been synthesized and screened for their anti-inflammatory and antioxidant activities. These compounds have been synthesized by refluxing intermediate <img src='/image/spc_char/alpha.gif' border=0> -benzamido-cinnamhydrazide with substituted benzaldehydes in the presence of a few drops of glacial acetic acid. The intermediate a-benzamido-cinnamhydrazide<b style=""> </b>is prepared by stirring 4-benzyli­dene-2-phenyl oxazole-5-one with hydrazine hydrate in presence of absolute ethanol. The chemical structures of the compounds are established by IR, <sup>1</sup>H NMR and mass spectral data. Of all the compounds screened, compound <b style="">3m</b> N'-(5-bromo-4-hydroxy-3-methoxybenzylidene)-2-(benzamido)-3-phenyla­cry­lo­hydrazide shows anti-inflammatory activity (75%) which is equivalent to that produced by the same dose (100 mg/kg) of phenylbutazone (74%). Compound <b style="">3l</b> N'-(4-hydroxy-3-methoxy benzylidene)-2-(benzamido)-3-phenyl acrylohydrazide, shows good anti-inflammatory and antioxidant activity.
Description: 729-733
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.50B(05) [May 2011]

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