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Title: Synthesis and evaluation of N-( -benzamido cinnamoyl) aryl hydrazone derivatives for anti-inflammatory and antioxidant activities
Authors: Rajitha, G
Saideepa, N
Praneetha, P
Keywords: Acylhydrazone;Hydrazone;Anti-inflammatory;Antioxidant activity
Issue Date: May-2011
Publisher: NISCAIR-CSIR, India
Abstract: A series of novel N-(-benzamido cinnamoyl) aryl hydrazone derivatives 3a-m have been synthesized and screened for their anti-inflammatory and antioxidant activities. These compounds have been synthesized by refluxing intermediate -benzamido-cinnamhydrazide with substituted benzaldehydes in the presence of a few drops of glacial acetic acid. The intermediate a-benzamido-cinnamhydrazide is prepared by stirring 4-benzyli­dene-2-phenyl oxazole-5-one with hydrazine hydrate in presence of absolute ethanol. The chemical structures of the compounds are established by IR, 1H NMR and mass spectral data. Of all the compounds screened, compound 3m N'-(5-bromo-4-hydroxy-3-methoxybenzylidene)-2-(benzamido)-3-phenyla­cry­lo­hydrazide shows anti-inflammatory activity (75%) which is equivalent to that produced by the same dose (100 mg/kg) of phenylbutazone (74%). Compound 3l N'-(4-hydroxy-3-methoxy benzylidene)-2-(benzamido)-3-phenyl acrylohydrazide, shows good anti-inflammatory and antioxidant activity.
Page(s): 729-733
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.50B(05) [May 2011]

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