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dc.contributor.authorDas, Ratnesh-
dc.contributor.authorPitre, K S-
dc.description.abstractThe anti-HIV drug 3'-Azido-3'-deoxythymidine (Zidovudine) AZT has been quantitatively and qualitatively analysed by direct current polarographic (DCP), differential pulse polarographic (DPP) and amperometric techniques. AZT gives a well-defined polarographic reduction wave/peak with E1/2/Ep = - 1.42/ - 1.44 V versus SCE in 0.2 M KCL at pH = 6.0 ± 0.1. Fe (II)-AZT complex has been studied both in solid and aqueous phases. The IR spectral data on the drug and its Fe (II)-complex revealed complexation through -N atom of azide group. The data showed a shift in the band due to azide group in the complex from 2170 to 2150 cm⁻¹ in case of pure drug zidovudine. Hence, a tentative structure of the complex has been suggested. Antibacterial activity of the complex has been determined using Raper's paper disc method against Escherichia coli, Salmonella typhi, Vibrio cholerae, and Diplococcus pneumoniae bacteria. Looking at its increased inhibition power against the above test pathogens, it is presumed that the complex may prove to be more potent against HIV, as compared to AZT drug.en_US
dc.relation.ispartofseriesA61K, A01N59/00en_US
dc.sourceIJCT Vol.14(5) [September 2007]en_US
dc.subjectAnti-HIV drugen_US
dc.titleBioinorganic studies on Fe (II)- zidovudine (azt) complexen_US
Appears in Collections:IJCT Vol.14(5) [September 2007]

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