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|Title:||Hybrid macrocyclic receptors based on lower rim functionalised thiacalixarene and amino acids: Synthesis, structure and binding properties towards metal ions|
Ganga, Viswanathan Bhagavathy
Varma, Ramavarma Luxmi
|Abstract:||Peptidothiacalixarene derivatives 4a-d and 7a-d have been synthesized in excellent yields by the reaction of methyl esters of glycine, l-alanine and d- and l-phenyl alanine with lower rim substituted 1,3-diacid chloride and tetraacid chloride derivatives of thiacalixarene. The conformational and hydrogen bonding properties of these conjugates have been investigated by means of 1H NMR in the solution state and by X-ray crystallography in the solid state. Complexation studies performed by UV-Vis and 1H NMR spectroscopy in acetonitrile solution show that the 1,3-disubstituted hybrids selectively bind Hg2+ ions and the orientation of the substituent on the chiral carbon is found to have a significant effect on the binding.|
|Appears in Collections:||IJC-B Vol.50B(05) [May 2011]|
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