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|Title:||Hybrid macrocyclic receptors based on lower rim functionalised thiacalixarene and amino acids: Synthesis, structure and binding properties towards metal ions|
Ganga, Viswanathan Bhagavathy
Varma, Ramavarma Luxmi
|Abstract:||Peptidothiacalixarene derivatives <b style="">4a-d </b>and<b style=""> 7a-d</b> have been synthesized in excellent yields by the reaction of methyl esters of glycine, l-alanine and d- and l-phenyl alanine with lower rim substituted 1,3-diacid chloride and tetraacid chloride derivatives of thiacalixarene. The conformational and hydrogen bonding properties of these conjugates have been investigated by means of <sup>1</sup>H NMR in the solution state and by X-ray crystallography in the solid state. Complexation studies performed by UV-Vis and <sup>1</sup>H NMR spectroscopy in acetonitrile solution show that the 1,3-disubstituted hybrids selectively bind Hg<sup>2+</sup> ions and the orientation of the substituent on the chiral carbon is found to have a significant effect on the binding.|
|Appears in Collections:||IJC-B Vol.50B(05) [May 2011]|
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