|
NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.50B [2011] >
IJC-B Vol.50B(05) [May 2011] >
| Title: | Design, synthesis and antibacterial activity of novel N-formylhydroxylamine derivatives as PDF inhibitors |
| Authors: | Yin, L
Jia, J
Zhao, G L
Xu, W R
Tang, L D
Wang, J W |
| Keywords: | Peptide deformylase (PDF)
N-formylhydroxylamine derivatives
Antibacterial activity |
| Issue Date: | May-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | A new series of N-formylhydroxylamines 11a-i
have been synthesized through a multi-step protocol starting from diethyl
malonate. These
compounds have been structurally characterized by IR, 1H NMR and
HRMS. All the synthesized compounds 11a-i have been screened for
antibacterial activities. All the compounds are found to exhibit potent in vitro inhibitory activity against Staphylococcus aureus and relatively
weak antibacterial activity against Klebsiella
pneumoniae. |
| Page(s): | 695-703 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.50B(05) [May 2011]
|
|
