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Title: Design, synthesis and antibacterial activity of novel N-formylhydroxylamine derivatives as PDF inhibitors
Authors: Yin, L
Jia, J
Zhao, G L
Xu, W R
Tang, L D
Wang, J W
Keywords: Peptide deformylase (PDF);N-formylhydroxylamine derivatives;Antibacterial activity
Issue Date: May-2011
Publisher: NISCAIR-CSIR, India
Abstract: A new series of N-formylhydroxylamines 11a-i have been synthesized through a multi-step protocol starting from diethyl malonate. These compounds have been structurally characterized by IR, 1H NMR and HRMS. All the synthesized compounds 11a-i have been screened for antibacterial activities. All the compounds are found to exhibit potent in vitro inhibitory activity against Staphylococcus aureus and relatively weak antibacterial activity against Klebsiella pneumoniae.
Page(s): 695-703
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.50B(05) [May 2011]

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