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Title: Design, synthesis and antibacterial activity of novel <i style="">N</i>-formylhydroxylamine derivatives as PDF inhibitors
Authors: Yin, L
Jia, J
Zhao, G L
Xu, W R
Tang, L D
Wang, J W
Keywords: Peptide deformylase (PDF)
<i style="">N-</i>formylhydroxylamine derivatives
Antibacterial activity
Issue Date: May-2011
Publisher: NISCAIR-CSIR, India
Abstract: A new series of <i style="">N</i>-formylhydroxylamines <b style="">11a-i</b> have been synthesized through a multi-step protocol starting from diethyl malonate. These compounds have been structurally characterized by IR, <sup>1</sup>H NMR and HRMS. All the synthesized compounds <b style="">11a-i</b> have been screened for antibacterial activities. All the compounds are found to exhibit potent <i style="">in vitro</i> inhibitory activity against <i style="">Staphylococcus aureus</i> and relatively weak antibacterial activity against <i style="">Klebsiella pneumoniae</i>.
Description: 695-703
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.50B(05) [May 2011]

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