Please use this identifier to cite or link to this item:
Title: Development and validation of spectrophotometric method for estimation of anti-asthmatic drug doxofylline in bulk and pharmaceutical formulation
Authors: Kamila, M M
Mondal, N
Ghosh, L K
Keywords: Doxofylline
UV spectrophotometry
ICH guidelines
Issue Date: Sep-2007
Publisher: CSIR
Series/Report no.: G01J3/00, A61K
Abstract: A simple, sensitive and accurate UV spectrophotometric method has been developed for the determination of an anti-asthmatic drug, doxofylline, in raw material and in tablets. The drug showed maximum absorption at 272 nm in water. Beer’s law was obeyed in the concentration range 5-50 μg mL⁻¹ of drug with an apparent molar absorptivity and Sandell sensitivity of 6.2 x 10³ L.mol⁻¹cm⁻¹ and 0.0363 μg cm⁻²/0.001A, respectively. The limits of detection and quantification were calculated to be 0.9623 and 2.9161 μg mL⁻¹, respectively. The method was successfully applied to the determination of doxofylline in tablets. Results were validated statistically as per ICH guidelines. It was found that the excipients present in the commercial formulation did not interfere with the method.
Description: 523-525
ISSN: 0971–457X
Appears in Collections:IJCT Vol.14(5) [September 2007]

Files in This Item:
File Description SizeFormat 
IJCT 14(5) (2007) 523-525.pdf97.96 kBAdobe PDFView/Open

Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.