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Journal of Scientific and Industrial Research (JSIR) >
JSIR Vol.70 [2011] >
JSIR Vol.70(05) [May 2011] >
| Title: | Development and validation of stability indicating spectrophotometric methods for determination of oxcarbazepine in pharmaceuticals |
| Authors: | Basavaiah, K
Rajendraprasad, N
Cijo, M X
Vinay, K B
Ramesh, P J |
| Keywords: | Assay
Oxcarbazepine
Pharmaceuticals
Stability indicating
UV-spectrophotometry |
| Issue Date: | May-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Two simple, selective
and stability indicating UV-spectrophotometric methods have been developed and
validated for assay of oxcarbazepine (OXC) in bulk drug and in its dosage
forms. Proposed methods are based on measurement of absorbance of OXC either in
methanol (method A) or in acetonitrile (method B) at 254 nm. Calibration graphs
are linear over 2-40  g ml-1 in both methods with correlation
coefficients (r) 0.9993 (method A) and 0.9999 (method B). Apparent molar
absorptivity values were 6.73 × 103 (method A) and 6.95 × 103
l mol-1 cm-1 (method B). This study indicated that OXC
was degraded in alkaline medium. Proposed methods were successfully applied to
determination of OXC in tablets and results are comparable with reported
method. |
| Page(s): | 346-351 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1084 (Online); 0022-4456 (Print) |
| Source: | JSIR Vol.70(05) [May 2011]
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