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Research Journals >
Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.49 [2011] >
IJEB Vol.49(05) [May 2011] >
| Title: | Anxiolytic effects of Equisetum arvense Linn. extracts in mice |
| Authors: | Singh, Navdeep
Kaur, Sarabjit
Bedi, P M S
Kaur, Divneet |
| Keywords: | Anti-anxiety
Equisetum arvense
Ethanol extract
Sedative |
| Issue Date: | May-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | The petroleum ether (PE), chloroform (CH), ethanol (ETH) and water extracts
of E. arvense stems were
evaluated for anti-anxiety activity
in mice using elevated plus maze model. Ketamine induced hypnosis and
actophotometer was used to evaluate sedative effect with various extracts in
mice. The results were compared with standard drug diazepam. The ethanolic
extract of E. arvense (50
and 100 mg/kg) significantly increased the time-spent and the percentage of the
open arm entries in the elevated plus-maze model which was comparable to
diazepam. Ethanolic extract (100 mg/kg) prolonged the ketamine-induced total
sleeping time and decreased the locomotor activity in mice. The results suggest
that the ethanolic extract of E. arvense seems to possess anxiolytic effect
with lower sedative activity than that of diazepam. The results could be
attributed to the flavonoid content of the ethanolic extract. |
| Page(s): | 352-356 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.49(05) [May 2011]
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