|
NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.49 [2011] >
IJEB Vol.49(05) [May 2011] >
| Title: | Protective effect of aqueous extract of Bombax malabaricum DC on experimental models of inflammatory bowel disease in rats and mice |
| Authors: | Jagtap, A G
Niphadkar, P V
Phadke, A S |
| Keywords: | Bombax malabaricum
Colitis
Inflammatory bowel disease
Myeloperoxidase |
| Issue Date: | May-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | There is little evidence regarding role of B.
malabaricum in the treatment of inflammatory bowel disease (IBD); though it
is clinically employed as a constituent of a polyherbal preparation for IBD. To
establish its role as a monotherapy for IBD, preliminary phytochemical
screening of aqueous extract of B. malabaricum (AEBM) was undertaken.
Subsequently, its protective effect in indomethacin and iodoacetamide induced
colitis in rats (45, 90, 180, 270 mg/kg) and acetic acid induced colitis in
mice (65, 130, 250, 500 mg/kg) was assessed. AEBM (270 mg/kg) in indomethacin
and iodoacetamide induced colitis significantly reduced the ulcer score and myeloperoxidase
(MPO) activity. AEBM/500 mg/kg dose/significantly reduced the ulcer score and
MPO activity in acetic acid induced colitis. The extract (270 mg/kg in rats and
500 mg/kg in mice) was found to be comparable with prednisolone (10 mg/kg) and
5-aminosalicylic acid (5-ASA) (100 mg/kg) used as standard treatments. AEBM
provided reduction in edema of the intestinal tissues, ulcer protection and
lowering of MPO activity in a dose dependent manner. AEBM (500 mg/kg)
significantly reduced colonic and serum TNF-α level when compared with the
positive control in acetic acid induced colitis model. The results suggest a
protective role of AEBM in IBD. |
| Page(s): | 343-351 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.49(05) [May 2011]
|
|
