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Title: Alpha-adrenergic receptor blocking effect of Cleistanthus collinus (Roxb.) Benth. and Hook f. leaf extract on guinea pig isolated smooth muscle preparations
Authors: Kumar, M Ravindra
Ramaswamy, S
Jayanthi, M
Raveendran, R
Keywords: α-adrenergic;Antagonist;Cleistanthus collinus;Poisonous
Issue Date: May-2011
Publisher: NISCAIR-CSIR, India
Abstract: Aqueous extract of C. collinus leaves inhibited norepinephrine induced contraction in guinea pig vas deferens and aortic strip in a dose-dependent manner. Inhibition of acetylcholine induced contraction in ileum was dose independent. C. collinus extract per se had no effect on isolated guinea pig vas deferens and aortic strip, but inhibited norepinephrine induced contraction in a dose-dependent manner probably by its antagonist action on α-adrenergic receptor. It had inconsistent effect on guinea pig ileum in vitro preparation.
Page(s): 339-342
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.49(05) [May 2011]

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