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NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
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Research Journals >
Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.49 [2011] >
IJEB Vol.49(05) [May 2011] >
| Title: | Metformin: An effective attenuator of risperidone-induced insulin resistance hyperglycemia and dyslipidemia in rats |
| Authors: | Adeneye, Adejuwon A
Agbaje, Esther O
Olagunju, Joseph A |
| Keywords: | Glibenclamide
Insulin resistance
Metformin
Rats
Risperidone |
| Issue Date: | May-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | The
use of atypical antipsychotics in the clinical management of schizophrenia and
schizoaffective disorders has been associated with the development of insulin
resistance. The present study evaluates the possible individual ameliorating
effect of single daily oral treatments with 20 mg/kg/day of metformin and 0.1
mg/kg of glibenclamide in two groups of Wistar rats pretreated with 0.2 mg/kg of
risperidone for 60 days. Two additional groups of rats were only treated with
0.2 mg/kg of risperidone and 10 mL/kg of distilled water, respectively, also
for 60 days. Results showed that oral pre-treatment with metformin
significantly attenuated increases in the weight gain pattern, fasting glucose,
fasting plasma insulin, serum triglyceride and total cholesterol levels that
were elevated by risperidone treatment. Metformin also significantly reduced
glycosylated hemoglobin concentration, fasting insulin-glucose ratio and
fasting insulin resistance index. Conversely, oral pre-treatment with
glibenclamide for 60 days did not significantly reduce any of the measured
parameters except for glycosylated hemoglobin concentrations. Thus, results of
this study showed that 20 mg/kg of metformin effectively ameliorated the
development of risperidone-induced insulin resistance and dyslipidemia which
was mediated via improvement in insulin resistance. This study provides insight
into the therapeutic potential of metformin in preventing risperidone-induced
insulin resistance diabetes mellitus and dyslipidaemia. |
| Page(s): | 332-338 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.49(05) [May 2011]
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