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Title: Kinetics and mechanism of the reaction of ranitidine hydrochloride with trans-(diaqua)(N,N-ethylene-bis-salicylamide) chromium(III) and hexa-aquachromium(III) ion – a comparative study
Authors: Dash, S C
Das, N N
Mohanty, P
Keywords: Ranitidine hydrochloride Metal Complexes;Chromium(III)-ranitidine complex
Issue Date: Mar-2011
Publisher: NISCAIR-CSIR, India
Abstract: The substitution reactions of [Cr(SALM)(OH2)2]+ (SALM =N, N– ethylene–bis-salicylamide) and Cr(H2O)63+ with ranitidine hydrochloride, an antacid have been studied spectrophotometrically over the range 0.5 ´ 10-4 £ [Cr(III)complex]T £ 3 ´10-4, 3.6 £ pH £ 4.2, 25oC £ t £ 45oC and I = 0.5 mol dm-3 [Cr(III)complex] = ([Cr (III)(SALM)(OH2)2]+or [Cr(H2O)6]3+]) . This reaction follows a mechanism which takes place via an outer sphere association between [Cr (III)(SALM)(OH2)2]+, [Cr(H2O)6]3+ and ranitidine hydrochloride followed by transformation of outer into inner sphere complex by slow interchange. The anation rate constant at 25oC and I = 0.5 mol dm-3 (NaClO4) is found to be 4.43 ´ 10-4 s-1 for [Cr(III)(SALM) (OH2)2]+and 3.05´10-4 s-1 for Cr(H2O)63+ . The DH# for kan path are found to be 48.2 ± 0.6, 41.2 ±0.2 kJmol-1 and S# –147.6 ± 2.0, -174.2 ± 0.6 JK-1mol-1 for Cr(III)SALM(OH2)2+ and Cr(H2O)63+ ion respectively.
Page(s): 132-136
ISSN: 0975-0991 (Online); 0971-457X (Print)
Appears in Collections:IJCT Vol.18(2) [March 2011]

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