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Title: Kinetics and mechanism of the reaction of ranitidine hydrochloride with trans-(diaqua)(N,N<sup>’</sup>-ethylene-bis-salicylamide) chromium(III) and hexa-aquachromium(III) ion – a comparative study
Authors: Dash, S C
Das, N N
Mohanty, P
Keywords: Ranitidine hydrochloride Metal Complexes
Chromium(III)-ranitidine complex
Issue Date: Mar-2011
Publisher: NISCAIR-CSIR, India
Abstract: The substitution reactions of [Cr(SALM)(OH<sub>2</sub>)<sub>2</sub>]<sup>+</sup> (SALM =N, N<sup>’</sup>– ethylene–bis-salicylamide) and Cr(H<sub>2</sub>O)<sub>6</sub><sup>3<b>+</b></sup> with ranitidine hydrochloride, an antacid have been studied spectrophotometrically over the range 0.5 ´ 10<sup>-4</sup> £ [Cr(III)complex]<sub>T</sub> £ 3 ´10<sup>-4</sup>, 3.6 £ pH £ 4.2, 25<sup>o</sup>C £ <i style="">t</i> £ 45<sup>o</sup>C and <i style="">I</i> = 0.5 mol dm<sup>-3</sup> [Cr(III)complex] = ([Cr (III)(SALM)(OH<sub>2</sub>)<sub>2</sub>]<sup>+</sup>or [Cr(H<sub>2</sub>O)<sub>6</sub>]<sup>3<b>+</b></sup>]<b>)</b> . This reaction follows a mechanism which takes place via an outer sphere association between [Cr (III)(SALM)(OH<sub>2</sub>)<sub>2</sub>]<sup>+</sup>, [Cr(H<sub>2</sub>O)<sub>6</sub>]<sup>3<b>+</b></sup> and ranitidine hydrochloride followed by transformation of outer into inner sphere complex by slow interchange. The anation rate constant at 25<sup>o</sup>C and <i style="">I</i> = 0.5 mol dm<sup>-3</sup> (NaClO<sub>4</sub>) is found to be 4.43 ´ 10<sup>-4</sup> s<sup>-1</sup> for [Cr(III)(SALM) (OH<sub>2</sub>)<sub>2</sub>]<sup>+</sup>and 3.05´10<sup>-4</sup> s<sup>-1</sup> for Cr(H<sub>2</sub>O)<sub>6</sub><sup>3<b>+</b></sup> . The D<i style="">H</i><sup>#</sup> for <i style="">k</i><sub>an</sub> path are found to be 48.2 ± 0.6, 41.2 ±0.2 kJmol<sup>-1 </sup>and <img src='/image/spc_char/delta.gif' border=0><i style="">S</i><sup>#</sup> –147.6 ± 2.0, -174.2 ± 0.6 JK<sup>-1</sup>mol<sup>-1</sup> for Cr(III)SALM(OH<sub>2</sub>)<sub>2</sub><sup>+</sup> and Cr(H<sub>2</sub>O)<sub>6</sub><sup>3<b>+</b></sup> ion respectively.
Description: 132-136
ISSN: 0975-0991 (Online); 0971-457X (Print)
Appears in Collections:IJCT Vol.18(2) [March 2011]

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