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Indian Journal of Chemical Technology (IJCT) >
IJCT Vol.18 [2011] >
IJCT Vol.18(2) [March 2011] >
| Title: | Kinetics and mechanism of the reaction of ranitidine hydrochloride with trans-(diaqua)(N,N’-ethylene-bis-salicylamide) chromium(III) and hexa-aquachromium(III) ion – a comparative study |
| Authors: | Dash, S C
Das, N N
Mohanty, P |
| Keywords: | Ranitidine hydrochloride Metal Complexes
Chromium(III)-ranitidine complex |
| Issue Date: | Mar-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | The substitution reactions of [Cr(SALM)(OH2)2]+
(SALM =N, N’– ethylene–bis-salicylamide) and Cr(H2O)63+
with ranitidine hydrochloride, an antacid have been studied
spectrophotometrically over the range 0.5 ´ 10-4 £
[Cr(III)complex]T £ 3 ´10-4, 3.6 £ pH £ 4.2, 25oC £ t £ 45oC and I =
0.5 mol dm-3 [Cr(III)complex] = ([Cr (III)(SALM)(OH2)2]+or
[Cr(H2O)6]3+]) . This reaction follows a mechanism which takes place
via an outer sphere association between
[Cr (III)(SALM)(OH2)2]+,
[Cr(H2O)6]3+ and ranitidine
hydrochloride followed by transformation of outer into inner sphere complex by
slow interchange. The anation rate constant at 25oC and I = 0.5 mol dm-3 (NaClO4)
is found to be 4.43 ´ 10-4 s-1 for
[Cr(III)(SALM) (OH2)2]+and 3.05´10-4
s-1 for Cr(H2O)63+ . The DH# for kan
path are found to be 48.2 ± 0.6, 41.2 ±0.2 kJmol-1 and  S# –147.6 ± 2.0,
-174.2 ± 0.6 JK-1mol-1 for
Cr(III)SALM(OH2)2+ and Cr(H2O)63+
ion respectively. |
| Page(s): | 132-136 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0991 (Online); 0971-457X (Print) |
| Source: | IJCT Vol.18(2) [March 2011]
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