23-May-2013
06:25:15 IST
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NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Biochemistry and Biophysics (IJBB) >
IJBB Vol.48 [2011] >
IJBB Vol.48(2) [April 2011] >
| Title: | Abnormality of Circadian Rhythm of Serum Melatonin and Other Biochemical Parameters in Fibromyalgia Syndrome |
| Authors: | Mahdi, Abbas Ali
Fatima, Ghizal
Das, Siddhartha Kumar
Verma, Nar Singh |
| Keywords: | Fibromyalgia syndrome
Circadian rhythm, Melatonin
Cortisol
Serotonin
IL-6
TNF-alpha |
| Issue Date: | Apr-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Fibromyalgia syndrome (FMS) is a complex chronic
condition causing widespread pain and variety of other symptoms. It produces
pain in the soft tissues located around joints throughout the body. FMS has
unknown etiology and its pathophysiology is not fully understood. However,
abnormality in circadian rhythm of hormonal profiles and cytokines has been
observed in this disorder. Moreover, there are reports of deficiency of
serotonin, melatonin, cortisol and cytokines in FMS patients, which are fully
regulated by circadian rhythm. Melatonin, the
primary hormone of the pineal gland regulates the body’s circadian rhythm and
normally its levels begin to rise in the mid-to-late evening, remain high for
most of the night, and then decrease in the early morning. FMS patients
have lower melatonin secretion during the hours of darkness than the healthy
subjects. This may contribute to impaired sleep at night, fatigue during the
day and changed pain perception. Studies have shown blunting of normal diurnal
cortisol rhythm, with elevated evening serum cortisol level in patients with
FMS. Thus, due to
perturbed level of cortisol secretion several symptoms of FMS may occur. Moreover,
disturbed cytokine levels have also been reported in FMS patients. Therefore, circadian rhythm can be an important
factor in the pathophysiology, diagnosis and treatment of FMS. This article
explores the circadian pattern of abnormalities in FMS patients, as this may
help in better understanding the role of variation in
symptoms of FMS and its possible relationship with circadian variations of
melatonin, cortisol, cytokines and serotonin levels.
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| Page(s): | 82-87 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0959 (Online); 0301-1208 (Print) |
| Source: | IJBB Vol.48(2) [April 2011]
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