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Indian Journal of Biochemistry and Biophysics (IJBB) >
IJBB Vol.48 [2011] >
IJBB Vol.48(2) [April 2011] >
| Title: | Role of PPAR , a Nuclear Hormone Receptor in Neuroprotection |
| Authors: | Gillespie, William
Tyagi, Neetu
Tyagi, Suresh C |
| Keywords: | PPAR
Neuronal death
Ischemia
Neurodegenerative disorder
Alzheimer’s disease
Parkinson’s disease
Multiple Sclerosis |
| Issue Date: | Apr-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Peroxisome proliferator-activated receptors
(PPARs) belong to the nuclear receptor superfamily. PPAR-alpha is involved in
wound healing, stimulation of lipid and folic acid catabolism, inflammation
control, inhibition of ureagenesis and peroxisome proliferation. The PPAR / is involved
wound healing, cell proliferation, embryo implantation, adipocyte
differentiation, myelination alteration and apoptosis. The PPAR is involved in fat, lipid and calorie utilization, sugar control,
inflammation control and macrophage (MQ) matutation. Homocysteine (Hcy) binds
to nuclear peroxisome proliferator activated receptor. Increase in PPAR
expression decreases the level of nitrotyrosine and increases endothelial
nitric oxide concentration, decreases metalloproteinase activity and expression
as well as elastinolysis and reverses
Hcy-mediated vascular dysfunction. The PPAR initially recognized as a regulator of adipocyte development has
become a potential therapeutic target for the treatment of diverse disorders.
In addition, the activation of PPAR receptor
ameliorates neurodegenerative disease. This review focuses on the recent
knowledge of PPAR in neuroprotection and deals with the
mechanism of neuroprotection of central nervous system disorder by PPAR. |
| Page(s): | 73-81 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0959 (Online); 0301-1208 (Print) |
| Source: | IJBB Vol.48(2) [April 2011]
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