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Title: Antiurolithiatic activity of <i>Crataeva magna</i> Lour. bark
Authors: Mekap, Suman Kumar
Mishra, Satyaranjan
Sahoo, Sabuj
Panda, Prasana Kumar
Keywords: Ammonium chloride
<i>Crataeva magna</i>
Ethylene glycol
Issue Date: Mar-2011
Publisher: NISCAIR-CSIR, India
Series/Report no.: <b style="">Int. cl.<sup> </sup>(2011.01)--</b> A61K 36/18, A61K 129/00, A61P 13/04
Abstract: <i>Crataeva magna </i>Lour. bark, commonly known as <i>Baruna</i>, belonging to family Capparaceae, has been investigated for its antiurolithiatic activity in two conventional models (<i style="">in vivo</i>) of Urolithiasis in rats. The two methods chosen were lactose (30%) + ethylene glycol (1%) and ammonium chloride (2%) + ethylene glycol (0.75%) induced urolithiasis, respectively. The ethanol extract (400 mg/kg bw) reduced the elevated levels of serum calcium (3.25 ± 0.30) and urine calcium (2.33 ± 0.18) significantly (<i>P</i>&lt;0.05), employing lactose (30%) + ethylene glycol (1%) induced urolithiasis model. The ethanol extract (400 mg/kg bw) reduced the urine uric acid level significantly employing both models, viz. lactose (30%) + ethylene glycol (1%) (0.82 ± 0.07; <i>P</i>&lt;0.001) and ammonium chloride (2%) + ethylene glycol (0.75%) (0.85 ± 0.12; <i>P</i>&lt;0.001) when compared to toxic group. The ethanol extract (400 mg/kg bw) employing both models resulted in reduced serum creatinine and calcium, urine oxalate and kidney weight significantly with a marked increase in final body weight and urine volume output when compared to toxic group. The results shown by the ethanol extract (400 mg/kg bw) group was compared to standard polyherbal drug (Cystone; 5 ml/kg bw) treated group and thus exhibited potent antiurolithiatic activity.
Description: 28-33
ISSN: 0975-1033 (Online); 0379-5136 (Print)
Appears in Collections:IJNPR Vol.2(1) [March 2011]

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