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Title: Antiurolithiatic activity of Crataeva magna Lour. bark
Authors: Mekap, Suman Kumar
Mishra, Satyaranjan
Sahoo, Sabuj
Panda, Prasana Kumar
Keywords: Ammonium chloride;Bark;Baruna;Crataeva magna;Ethylene glycol;Lactose;Urolithiasis.
Issue Date: Mar-2011
Publisher: NISCAIR-CSIR, India
IPC Code: Int. cl. (2011.01)-- A61K 36/18, A61K 129/00, A61P 13/04
Abstract: Crataeva magna Lour. bark, commonly known as Baruna, belonging to family Capparaceae, has been investigated for its antiurolithiatic activity in two conventional models (in vivo) of Urolithiasis in rats. The two methods chosen were lactose (30%) + ethylene glycol (1%) and ammonium chloride (2%) + ethylene glycol (0.75%) induced urolithiasis, respectively. The ethanol extract (400 mg/kg bw) reduced the elevated levels of serum calcium (3.25 ± 0.30) and urine calcium (2.33 ± 0.18) significantly (P<0.05), employing lactose (30%) + ethylene glycol (1%) induced urolithiasis model. The ethanol extract (400 mg/kg bw) reduced the urine uric acid level significantly employing both models, viz. lactose (30%) + ethylene glycol (1%) (0.82 ± 0.07; P<0.001) and ammonium chloride (2%) + ethylene glycol (0.75%) (0.85 ± 0.12; P<0.001) when compared to toxic group. The ethanol extract (400 mg/kg bw) employing both models resulted in reduced serum creatinine and calcium, urine oxalate and kidney weight significantly with a marked increase in final body weight and urine volume output when compared to toxic group. The results shown by the ethanol extract (400 mg/kg bw) group was compared to standard polyherbal drug (Cystone; 5 ml/kg bw) treated group and thus exhibited potent antiurolithiatic activity.
Page(s): 28-33
ISSN: 0975-1033 (Online); 0379-5136 (Print)
Appears in Collections:IJNPR Vol.2(1) [March 2011]

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