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Indian Journal of Natural Products and Resources (IJNPR)
[Formerly Natural Product Radiance (NPR)] >
IJNPR Vol.2 [2011] >
IJNPR Vol.2(1) [March 2011] >
| Title: | Antiurolithiatic activity of Crataeva magna Lour. bark |
| Authors: | Mekap, Suman Kumar
Mishra, Satyaranjan
Sahoo, Sabuj
Panda, Prasana Kumar |
| Keywords: | Ammonium chloride
Bark
Baruna
Crataeva magna
Ethylene glycol
Lactose
Urolithiasis. |
| Issue Date: | Mar-2011 |
| Publisher: | NISCAIR-CSIR, India |
| IPC Code: | Int. cl. (2011.01)-- A61K 36/18, A61K 129/00, A61P 13/04 |
| Abstract: | Crataeva
magna Lour. bark, commonly known as Baruna, belonging to family Capparaceae, has been investigated for
its antiurolithiatic activity in two conventional models (in vivo) of Urolithiasis in rats. The two methods chosen were lactose
(30%) + ethylene glycol (1%) and ammonium chloride (2%) + ethylene glycol
(0.75%) induced urolithiasis, respectively. The ethanol extract (400 mg/kg bw)
reduced the elevated levels of serum calcium (3.25 ± 0.30) and urine calcium (2.33 ± 0.18) significantly (P<0.05), employing
lactose (30%) + ethylene glycol (1%) induced urolithiasis model. The ethanol
extract (400 mg/kg bw) reduced the urine uric acid level significantly
employing both models, viz. lactose (30%) + ethylene glycol (1%) (0.82 ± 0.07; P<0.001) and ammonium chloride
(2%) + ethylene glycol (0.75%) (0.85 ± 0.12; P<0.001) when compared
to toxic group. The ethanol extract (400 mg/kg bw) employing both models
resulted in reduced serum creatinine and calcium, urine oxalate and kidney
weight significantly with a marked increase in final body weight and urine
volume output when compared to toxic group. The results shown by the ethanol
extract (400 mg/kg bw) group was compared to standard polyherbal drug (Cystone;
5 ml/kg bw) treated group and thus exhibited potent antiurolithiatic activity. |
| Page(s): | 28-33 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1033 (Online); 0379-5136 (Print) |
| Source: | IJNPR Vol.2(1) [March 2011]
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