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NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
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Research Journals >
Indian Journal of Natural Products and Resources (IJNPR)
[Formerly Natural Product Radiance (NPR)] >
IJNPR Vol.2 [2011] >
IJNPR Vol.2(1) [March 2011] >
| Title: | Ganoderma lucidum (Fr.) P. Karst occurring in South India attenuates gastric ulceration in rats |
| Authors: | Rony, K A
Mathew, John
Neenu, P P
Janardhanan, K K |
| Keywords: | Ganoderma lucidum
Indomethacin
Ulcer
Ethanol
South India |
| Issue Date: | Mar-2011 |
| Publisher: | NISCAIR-CSIR, India |
| IPC Code: | Int. cl. (2011.01)—A61K 36/00, A61P 1/04 |
| Abstract: | The ethanol extract of Ganoderma lucidum (Fr.) P. Karst occurring
in South India was examined for
antiulcer activity against ethanol and Indomethacin induced ulcer in rats.
Pretreatment of oral doses of 500 mg/kg and 1000 mg/kg showed significant
reduction of ulcer index, with a percentage of inhibition of 55.17, 72.79 and
47 and 76.14% in ethanol and Indomethacin induced gastric ulceration,
respectively. Administration of G. lucidum extract elevated the
levels of Glutathione (GSH) as well as activities of Superoxide dismutase
(SOD), Glutathione Peroxidase (GPx) and Catalase (CAT) and significantly
lowered the levels of lipid peroxidation (LPO) in a dose dependent manner. The
antiulcer property of the mushroom might be due to its profound free radical
scavenging activity. The findings suggest the potential therapeutic use of G. lucidum as an effective
non-toxic antiulcer agent. |
| Page(s): | 19-27 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1033 (Online); 0379-5136 (Print) |
| Source: | IJNPR Vol.2(1) [March 2011]
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