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IJBT Vol.10(2) [April 2011] >


Title: Codon usage pattern of differentially expressed genes in Leishmania species
Authors: Singh, Abhimanyu Kumar
Vidyarthi, Ambarish Sharan
Shankaracharya
Keywords: Effective number of codons
Leishmania infantum
L. major
Mutational pressure
Relative synonymous codon usage
Translational selection
Issue Date: Apr-2011
Publisher: NISCAIR-CSIR, India
Abstract: Out of numerous genes, differentially expressed genes of Leishmania major (299) and L. infantum (241), essential for their survival, have been studied for the analysis of synonymous codon usage patterns. The role of translational selection and mutational biases were analyzed through ENc plot and correspondence analysis. Present analysis indicates that mutational pressure has a profound effect on codon usage pattern in both the species of Leishmania (with a minor variation). Beside this, natural and translational selections also operate with a proper balance that makes the organism translationally more efficient.
Page(s): 188-195
CC License:  CC Attribution-Noncommercial-No Derivative Works 2.5 India
ISSN: 0975-0967 (Online); 0972-5849 (Print)
Source:IJBT Vol.10(2) [April 2011]

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