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dc.contributor.authorGeorge, Mary-
dc.contributor.authorBalasubramanian, N-
dc.contributor.authorNagaraja, K S-
dc.date.accessioned2008-04-24T05:00:17Z-
dc.date.available2008-04-24T05:00:17Z-
dc.date.issued2007-07-
dc.identifier.issn0971–457X-
dc.identifier.urihttp://hdl.handle.net/123456789/1143-
dc.description412-416en_US
dc.description.abstractHydroxylamine has been determined by its oxidation to nitrite with a known excess of bromine. Bromine in acidic medium bleaches the dye methyl red. A known excess of bromine when treated with hydroxylamine is reduced to bromide and the unreacted bromine is determined using methyl red. The method obeys Beer’s law in the range 0-5 μg of hydroxylamine in an overall aqueous volume of 25 mL. The relative standard deviation is 2.7% (n=10) at 3 μg of hydroxylamine. The molar absorptivity is calculated to be 9.8x10⁴ Lmol⁻¹cm⁻¹ with the correlation coefficient of 0.995. The developed method bas been applied for the determination of hydroxylamine and its derivatives after hydrolysis in drug formulations. The results obtained by the present method compare well with those obtained by the Verma-Gupta’s method and with the standard addition of hydroxylamine and recovery studies.en_US
dc.language.isoen_USen_US
dc.publisherCSIRen_US
dc.relation.ispartofseriesA61K, G01J3/00, C07C215/00en_US
dc.sourceIJCT Vol.14(4) [July 2007]en_US
dc.subjectSpectrophotometryen_US
dc.subjectHydroxylamineen_US
dc.subjectBromineen_US
dc.subjectMethyl reden_US
dc.titleSpectrophotometric determination of hydroxylamine and its derivatives in drug formulation using methyl reden_US
dc.typeArticleen_US
Appears in Collections:IJCT Vol.14(4) [July 2007]

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