NISCAIR Online Periodicals Repository

Research Journals >
Indian Journal of Chemical Technology (IJCT) >
IJCT Vol.14 [2007] >
IJCT Vol.14(4) [July 2007] >

Title: Spectrophotometric determination of hydroxylamine and its derivatives in drug formulation using methyl red
Authors: George, Mary
Balasubramanian, N
Nagaraja, K S
Keywords: Spectrophotometry
Methyl red
Issue Date: Jul-2007
Publisher: CSIR
IPC CodeA61K, G01J3/00, C07C215/00
Abstract: Hydroxylamine has been determined by its oxidation to nitrite with a known excess of bromine. Bromine in acidic medium bleaches the dye methyl red. A known excess of bromine when treated with hydroxylamine is reduced to bromide and the unreacted bromine is determined using methyl red. The method obeys Beer’s law in the range 0-5 μg of hydroxylamine in an overall aqueous volume of 25 mL. The relative standard deviation is 2.7% (n=10) at 3 μg of hydroxylamine. The molar absorptivity is calculated to be 9.8x10⁴ Lmol⁻¹cm⁻¹ with the correlation coefficient of 0.995. The developed method bas been applied for the determination of hydroxylamine and its derivatives after hydrolysis in drug formulations. The results obtained by the present method compare well with those obtained by the Verma-Gupta’s method and with the standard addition of hydroxylamine and recovery studies.
Page(s): 412-416
ISSN: 0971–457X
Source:IJCT Vol.14(4) [July 2007]

Files in This Item:

File Description SizeFormat
IJCT 14(4) (2007) 412-416.pdf89.6 kBAdobe PDFView/Open
 Current Page Visits: 123 
Recommend this item


Online Submission of Articles |  NISCAIR Website |  National Knowledge Resources Consortium |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2015 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 163558 since 01-Sep-2015  Last updated on 21-Jun-2016Webmaster: