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Title: Conventional and microwave induced synthesis of various pyrimidine and isoxazole derivatives from 1-{4'-[(4''-methyl­pipera­zinyl)diazenyl]phenyl}-3-(substituted­phe­nyl)­prop-2-en-1-one and studies of their antimicrobial activity
Authors: Mistry, B D
Desai, K R
Rana, P B
Keywords: Pyrimidine;Microwave irradiation;Antimicrobial activity;Spectral data
Issue Date: Apr-2011
Publisher: NISCAIR-CSIR, India
Abstract: A series of compounds namely 6-{4'-[(4''-methylpiperazinyl)­diazenyl]phenyl} -4-(substitutedphenyl)-3,4,5-trihydropyrimidin-2-one 3a-j, 6-{4'-[(4''-methylpiperazinyl) diazenyl]phenyl}-4-(substitutedphenyl)-3,4,5-trihydropyrimidin-2-thione 4a-j and 3-{4'-[(4''-methylpiperazinyl)diazenyl]phenyl}-5-(substituted­phe­nyl)­­­isoxazole 5a-j have been prepared by the reaction of chalcone derivative 1-{4'-[(4''-methylpiperazinyl)diazenyl] phenyl}-3-(substitutedphenyl)prop-2-en-1-one 2a-j with urea, thiourea and hydroxylamine hydrochloride respectively. The reactions have been carried out by both microwave and conventional methods. It is noteworthy that the reaction which requires 5-8 hr in conventional method, was completed within 3-6 min by microwave irradiation technique. The microwave-assisted reactions are carried out in a “Q-Pro-M-modified microwave system”. The compounds have been screened for their antimicrobial activities against different microorganisms at 128, 256 and 512 g/mL. The structures of novel synthesized compounds have been established on the basis of elemental analysis, IR, 1H NMR and mass spectral data.
Page(s): 627-633
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.50B(04) [April 2011]

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