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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.50B [2011] >
IJC-B Vol.50B(04) [April 2011] >
| Title: | Conventional and microwave induced synthesis of various pyrimidine and isoxazole derivatives from 1-{4'-[(4''-methylpiperazinyl)diazenyl]phenyl}-3-(substitutedphenyl)prop-2-en-1-one and studies of their antimicrobial activity |
| Authors: | Mistry, B D
Desai, K R
Rana, P B |
| Keywords: | Pyrimidine
Microwave irradiation
Antimicrobial activity
Spectral data |
| Issue Date: | Apr-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | A series of compounds
namely 6-{4'-[(4''-methylpiperazinyl)diazenyl]phenyl} -4-(substitutedphenyl)-3,4,5-trihydropyrimidin-2-one
3a-j, 6-{4'-[(4''-methylpiperazinyl)
diazenyl]phenyl}-4-(substitutedphenyl)-3,4,5-trihydropyrimidin-2-thione 4a-j and 3-{4'-[(4''-methylpiperazinyl)diazenyl]phenyl}-5-(substitutedphenyl)isoxazole
5a-j have been prepared by the
reaction of chalcone derivative 1-{4'-[(4''-methylpiperazinyl)diazenyl]
phenyl}-3-(substitutedphenyl)prop-2-en-1-one 2a-j with urea, thiourea and hydroxylamine hydrochloride
respectively. The reactions have been carried out by both microwave and
conventional methods. It is noteworthy that the reaction which requires 5-8 hr
in conventional method, was completed within 3-6 min by microwave irradiation
technique. The microwave-assisted reactions are carried out in a “Q-Pro-M-modified
microwave system”. The compounds have been screened for their antimicrobial
activities against different microorganisms at 128, 256 and 512  g/mL. The
structures of novel synthesized compounds have been established on the basis of
elemental analysis, IR, 1H NMR and mass spectral data. |
| Page(s): | 627-633 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.50B(04) [April 2011]
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