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Title: Facile one-pot synthesis of novel 3-substituted-1, 6-dihydro-1,2,4-triazin-5-(2H)-ones from fatty acid hydrazides and their in-vitro antimicrobial activity
Authors: Farshori, Nida Nayyar
Banday, Mudasir Rashid
Ahmad, Anis
Khan, Asad Ullah
Rauf, Abdul
Keywords: Fatty acid hydrazides;1,2,4-triazin-5-ones;IR;1H NMR;MS;Antimicrobial activity
Issue Date: Apr-2011
Publisher: NISCAIR-CSIR, India
Abstract: A series of 3-substituted-1,6-dihydro-1,2,4-triazin-5(2H)-ones, have been synthesized using the cyclocondensation reaction of fatty acid hydrazides with 2-chloroacetamide in N,N-dimethylformamide medium. The structural elucidation of the synthesized compounds is based on IR, 1H NMR, mass spectral data and elemental analysis. These compounds have been tested for their in-vitro antibacterial and antifungal activities. The MIC, MBC and MFC have also been determined.
Page(s): 605-610
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.50B(04) [April 2011]

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