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|Title:||Hepatoprotective action of ethanolic extracts of <i style="">Melia azedarach</i> Linn. and <i style="">Piper longum</i> Linn and their combination on CCl<sub>4</sub> induced hepatotoxicity in rats|
|Abstract:||A comparison of analysis in evaluating the hepatoprotective action of ethanolic extract of <i style="">M. azedarach</i> (MAE) and <i style="">P. longum </i>(PLE) with their combination biherbal extract (BHE) against carbon tetrachloride (CCl<sub>4</sub>) induced hepatic damage is reported in albino rats. There was a marked elevation of serum marker enzyme levels in CCl<sub>4</sub> treated rats, which were restored towards normalization in the drug (MAE and/or PLE:50 mg/kg body weight po, once daily for 14 days) treated animals. The biochemical parameters like total protein, total bilirubin, total cholesterol, triglycerides, and urea were also restored towards normal levels. The combined BHE<i style=""> </i>showed more significant reduction of the enzymes than MAE or PLE<i style=""> </i>against CCl<sub>4 </sub>induced hepatotoxicity. The results strongly indicate that BHE has more potent hepatoprotective action than MAE or PLE individually<i style=""> </i>against CCl<sub>4 </sub>induced hepatic damage in rats. Among these extracts, BHE showed similar hepatoprotective action to silymarin, which was the positive control in this study.|
|ISSN:||0975-1009 (Online); 0019-5189 (Print)|
|Appears in Collections:||IJEB Vol.49(04) [April 2011]|
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