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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.49 [2011] >
IJEB Vol.49(04) [April 2011] >
| Title: | Hepatoprotective action of ethanolic extracts of Melia azedarach Linn. and Piper longum Linn and their combination on CCl4 induced hepatotoxicity in rats |
| Authors: | Rajeswary, H
Vasuki, R
Samudram, P
Geetha, A |
| Keywords: | Biherbal extract
CCl4
Hepatoprotective
Marker enzymes |
| Issue Date: | Apr-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | A comparison of
analysis in evaluating the hepatoprotective action of ethanolic extract of M. azedarach (MAE) and
P. longum (PLE) with their
combination biherbal extract (BHE) against carbon tetrachloride (CCl4)
induced hepatic damage is reported in albino rats. There was a marked elevation
of serum marker enzyme levels in CCl4 treated rats, which were
restored towards normalization in the drug (MAE and/or PLE:50 mg/kg body weight
po, once daily for 14 days) treated animals. The biochemical parameters like total protein, total bilirubin, total
cholesterol, triglycerides, and urea were also restored towards normal levels.
The combined BHE showed more
significant reduction of the enzymes than MAE or PLE against CCl4 induced hepatotoxicity. The results
strongly indicate that BHE has more potent hepatoprotective action than MAE or
PLE individually against CCl4 induced
hepatic damage in rats. Among these extracts, BHE showed similar
hepatoprotective action to silymarin, which was the positive control in this
study. |
| Page(s): | 276-281 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.49(04) [April 2011]
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