|
NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.49 [2011] >
IJEB Vol.49(04) [April 2011] >
| Title: | Behavioural and neurochemical evaluation of Perment® an herbal formulation in chronic unpredictable mild stress induced depressive model |
| Authors: | Ramanathan, M
Balaji, B
Justin, A
Gopinath, N
Vasanthi, M
Ramesh, R V |
| Keywords: | Anxiety
Chronic mild stress
Corticosterone
Depression
Noradrenaline
Perment®
Serotonin |
| Issue Date: | Apr-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Perment®, a polyherbal Ayurvedic
formulation that contains equal parts of Clitoria ternatea Linn., Withania
somnifera Dun., Asparagus racemosus Linn., Bacopa monniera Linn.,
is used clinically as mood elevators. The aim of the present study was to
explore the behavioural effects and to understand possible mode of action of
Perment® in
stress induced depressive model. Chronic unpredictable mild stress (CUMS) was used to
induce depression in rats. Open field exploratory behaviour, elevated plus
maze, social interaction and behavioural despair tests were used to assess
behaviour. Using standard protocols plasma noradrenaline, serotonin, corticosterone and brain/adrenal corticosterone levels were measured to support the behavioural
effects of Perment®. Exposure to CUMS for 21 days
caused anxiety and depression in rats, as indicated by significant decrease in
locomotor activity in the open field exploratory behaviour test and increased
immobility period in the behavioural despair test. Perment® predominantly
exhibited antidepressant action than anxiolytic activity. Further Perment® increased
the plasma noradrenaline and serotonin levels in stressed rats. No significant
alteration in the brain corticosterone level
in stressed rats was observed with Perment® treatment. However the adrenal corticosterone level is
decreased with Perment®. It can be concluded that the Perment® formulation
exhibited synergistic activity, has a significant antidepressant and anxiolytic
activity, which may be mediated through adrenergic and serotonergic system
activation. Currently the formulation is clinically used as anxiolytic but the
present results suggest that the formulation can also be indicated in patients
affected with depression. |
| Page(s): | 269-275 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.49(04) [April 2011]
|
|
