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Title: Recent thiazolidinediones as antidiabetics
Authors: Imran, Mohd
Ilyas, Babar
Khan, Suroor Ahmad
Keywords: Insulin sensitizing agents
Type 2 diabetes
Issue Date: Feb-2007
Publisher: CSIR
Abstract: Thiazolidinediones, a class of oral insulin sensitizing agents that improve insulin resistance, are agonists of peroxisome proliferator activated receptor-ϒ (PPAR-ϒ). Two clinically used drugs pioglitazone (ACTOS) and rosiglitazone (AVANDIA) have made a great contribution to therapy for type 2 diabetes. However, weight gain and hepatotoxicity are side effects of thiazolidinediones. For thiazolidinediones with lesser side effects, researchers are focusing on modification of side chain at C-5 of thiazolidinedione nucleus and its derivatization. Netoglitazone possesses both PPAR-⍺/ϒ dual agonistic activity. More thiazolidinedione derivatives like DRF-2189, PHT46, PMT13, DRF-2519 can be utilized as potent antidiabetic agents in future.
Page(s): 99-109
ISSN: 0022–4456
Source:JSIR Vol.66(02) [February 2007]

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