|
NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Journal of Scientific and Industrial Research (JSIR) >
JSIR Vol.66 [2007] >
JSIR Vol.66(02) [February 2007] >
| Title: | Recent thiazolidinediones as antidiabetics |
| Authors: | Imran, Mohd
Ilyas, Babar
Deepanjali
Khan, Suroor Ahmad |
| Keywords: | Insulin sensitizing agents
Netoglitazone
Thiazolidinediones
Type 2 diabetes |
| Issue Date: | Feb-2007 |
| Publisher: | CSIR |
| Abstract: | Thiazolidinediones, a class of oral insulin sensitizing agents that improve insulin resistance, are agonists of peroxisome
proliferator activated receptor-ϒ (PPAR-ϒ). Two clinically used drugs pioglitazone (ACTOS) and rosiglitazone (AVANDIA)
have made a great contribution to therapy for type 2 diabetes. However, weight gain and hepatotoxicity are side effects of
thiazolidinediones. For thiazolidinediones with lesser side effects, researchers are focusing on modification of side chain at
C-5 of thiazolidinedione nucleus and its derivatization. Netoglitazone possesses both PPAR-⍺/ϒ dual agonistic activity.
More thiazolidinedione derivatives like DRF-2189, PHT46, PMT13, DRF-2519 can be utilized as potent antidiabetic agents
in future. |
| Page(s): | 99-109 |
| ISSN: | 0022–4456 |
| Source: | JSIR Vol.66(02) [February 2007]
|
|
