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Research Journals >
Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.49 [2011] >
IJEB Vol.49(04) [April 2011] >
| Title: | Effect of Aloe vera (Aloe barbadensis Miller) gel on doxorubicin-induced myocardial oxidative stress and calcium overload in albino rats |
| Authors: | Kaithwas, Gaurav
Dubey, Kiran
Pillai, K K |
| Keywords: | Aloe vera gel
Antioxidants
Free Radicals
Magnesium
Polysaccharides |
| Issue Date: | Apr-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Administration
of a single dose of doxorubicin (DOX) (7.5 mg/kg, iv) produces cardiotoxicity,
manifested biochemically by significant decrease in blood glutathione (GSH) and
tissue GSH along with elevated levels of serum lactate dehydrogenase (LDH) and serum
creatine phosphokinase (CPK). In addition, cardiotoxicity was further confirmed
by significant increase in lipid peroxides expressed as malondialdehyde (MDA,
secondary indicator of lipid peroxidation), tissue catalase and tissue
superoxide dismutase (SOD). Administration of A. vera gel (100 and 200 mg/kg) orally for 10 days produced a
significant protection against cardiotoxicity induced by DOX evidenced by
significant reductions in serum LDH, serum CPK, cardiac lipid peroxides, tissue
catalase and tissue SOD along with increased levels of blood and tissue GSH. The
results revealed that A. vera gel produced
a dose dependent protection against DOX induced cardiotoxiaty. |
| Page(s): | 260-268 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.49(04) [April 2011]
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