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Title: <i>Mucuna pruriens </i>Linn. seed extract pretreatment protects against cardiorespiratory and neuromuscular depressant effects of <i>Naja sputatrix</i> (Javan spitting cobra) venom in rats
Authors: Fung, Shin Yee
Tan, Nget Hong
Sim, Si Mui
Marinello, Enrico
Guerranti, Roberto
Aguiyi, John Chinyere
Keywords: Antivenom effects
<i style="">Mucuna pruriens </i>seed
<i style="">Naja sputatrix</i> venom
Issue Date: Apr-2011
Publisher: NISCAIR-CSIR, India
Abstract: <i style="">Mucuna pruriens</i> has been used by native Nigerians as a prophylactic for snakebite. The protective effects of <i style="">M. pruriens</i> seed extract (MPE) were investigated against the pharmacological actions of <i style="">N. sputatrix</i> (Javan spitting cobra) venom in rats. The results showed that MPE-pretreatment protected against cardiorespiratory and, to a lesser extent, neuromuscular depressant effects of <i style="">N. sputatrix</i> venom. These may be explained at least in part by the neutralisation of the cobra venom toxins by anti-MPE antibodies elicited by the MPE pretreatment.
Description: 254-259
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.49(04) [April 2011]

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