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Research Journals >
Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.49 [2011] >
IJEB Vol.49(04) [April 2011] >
| Title: | Mucuna pruriens Linn. seed extract pretreatment protects against cardiorespiratory and neuromuscular depressant effects of Naja sputatrix (Javan spitting cobra) venom in rats |
| Authors: | Fung, Shin Yee
Tan, Nget Hong
Sim, Si Mui
Marinello, Enrico
Guerranti, Roberto
Aguiyi, John Chinyere |
| Keywords: | Antivenom effects
Immunology
Mucuna pruriens seed
Naja sputatrix venom |
| Issue Date: | Apr-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Mucuna pruriens has been used by native Nigerians as a
prophylactic for snakebite. The protective effects of M. pruriens seed extract (MPE) were investigated against the
pharmacological actions of N. sputatrix
(Javan spitting cobra) venom in rats. The results showed that MPE-pretreatment
protected against cardiorespiratory and, to a lesser extent, neuromuscular
depressant effects of N. sputatrix
venom. These may be explained at least in part by the neutralisation of the
cobra venom toxins by anti-MPE antibodies elicited by the MPE pretreatment. |
| Page(s): | 254-259 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.49(04) [April 2011]
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