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http://nopr.niscair.res.in/handle/123456789/11388| Title: | Mucuna pruriens Linn. seed extract pretreatment protects against cardiorespiratory and neuromuscular depressant effects of Naja sputatrix (Javan spitting cobra) venom in rats |
| Authors: | Fung, Shin Yee Tan, Nget Hong Sim, Si Mui Marinello, Enrico Guerranti, Roberto Aguiyi, John Chinyere |
| Keywords: | Antivenom effects;Immunology;Mucuna pruriens seed;Naja sputatrix venom |
| Issue Date: | Apr-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Mucuna pruriens has been used by native Nigerians as a prophylactic for snakebite. The protective effects of M. pruriens seed extract (MPE) were investigated against the pharmacological actions of N. sputatrix (Javan spitting cobra) venom in rats. The results showed that MPE-pretreatment protected against cardiorespiratory and, to a lesser extent, neuromuscular depressant effects of N. sputatrix venom. These may be explained at least in part by the neutralisation of the cobra venom toxins by anti-MPE antibodies elicited by the MPE pretreatment. |
| Page(s): | 254-259 |
| URI: | http://hdl.handle.net/123456789/11388 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Appears in Collections: | IJEB Vol.49(04) [April 2011] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJEB 49(4) 254-259.pdf | 697.04 kB | Adobe PDF | View/Open |
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