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NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
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Research Journals >
Indian Journal of Biotechnology (IJBT) >
IJBT Vol.02 [2003] >
IJBT Vol.02(3) [July 2003] >
| Title: | Mycobacterial  -Lactamases: An Overview |
| Authors: | Nampoothiri, K Madhavan |
| Keywords: | Mycobacterium
-lactamases
Penicillin binding proteins |
| Issue Date: | Jul-2003 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Despite of four decades of effective
chemotherapy, tuberculosis has re-emerged as one of the leading causes of death.
Prevention and control of tuberculosis got a great setback by the appearance of
multidrug resistant strains of M. tuberculosis. New antibiotic regiments
are needed for the treatment of multidrug resistant tuberculosis. -Lactam antibiotics
that inhibit trans peptidase reactions and prevent cell wall assembly in
bacteria are the most widely used antimicrobial agents. However, most of the
mycobacteria are naturally resistant to -lactams,presumably because of their
extremely hydrophobic cell wall, presence of periplamsic penicillin binding
proteins (PPHS) and most importantly the presence of an active -lactamase.This paper details the various studies on -lactamasesof Mycobacterium
and highlights the importance of -lactamases,in future, for developing an
effective drug combination comprising a -lactamantibiotic in combination with -lactamaseinhibitors. |
| Page(s): | 342-345 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0967 (Online); 0972-5849 (Print) |
| Source: | IJBT Vol.02(3) [July 2003]
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