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|Title:||Mycobacterial -Lactamases: An Overview|
|Authors:||Nampoothiri, K Madhavan|
Penicillin binding proteins
|Abstract:||Despite of four decades of effective chemotherapy, tuberculosis has re-emerged as one of the leading causes of death. Prevention and control of tuberculosis got a great setback by the appearance of multidrug resistant strains of M. tuberculosis. New antibiotic regiments are needed for the treatment of multidrug resistant tuberculosis. -Lactam antibiotics that inhibit trans peptidase reactions and prevent cell wall assembly in bacteria are the most widely used antimicrobial agents. However, most of the mycobacteria are naturally resistant to -lactams,presumably because of their extremely hydrophobic cell wall, presence of periplamsic penicillin binding proteins (PPHS) and most importantly the presence of an active -lactamase.This paper details the various studies on -lactamasesof Mycobacterium and highlights the importance of -lactamases,in future, for developing an effective drug combination comprising a -lactamantibiotic in combination with -lactamaseinhibitors.|
|ISSN:||0975-0967 (Online); 0972-5849 (Print)|
|Appears in Collections:||IJBT Vol.02(3) [July 2003]|
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