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Title: Microbial Transformation of Rifamycin: A Novel Approach to Rifamycin Derivatives
Authors: Jobanputra, A H
Patil, G D
Sayyed, R Z
Chaudhari, A B
Chincholkar, S B
Keywords: Biotransformation
Rifamycin s
Rifamycin oxidase
Curvularia lunata
Monocillium
Humicola
Issue Date: Jul-2003
Publisher: NISCAIR-CSIR, India
Abstract: Biotransformation of an ansamycin group of antibiotic, rifamycin B (clinically less active) to a more potent antibiotic rifamycin S, involves the action of rifamycin oxidase. The extracellular rifamycin oxidase (RO) from Curvularia lunata offers ease in the process and increased biotransformation potential and yield. Extracellular RO from C. lunata deserves a great future since it shows higher activity and biotransformation potential vis-à-vis intracellular RO from Monocillium and Humicola. Rifamycin S, especiallyamong the derivatives, has been of great commercial significance as a key intermediate for the synthesis of several hundreds of semisynthetic rifamycins. Besides these, rifamycin S has broad-spectrum activity against Brucella, Chlamydia, Haemophilus, Helicobacter pylori, Legionella and Staphylococcus. It has also emerged as an antituberculosis and antileprosy drug. Chemical conversion of rifamycin B against microbial transformation has been discussed with special emphasis on biotransforming systems, characteristics of rifamycin oxidase and factors influencing the production of rifamycin oxidase and biotransformation of rifamycin B to S.
Page(s): 370-377
CC License:  CC Attribution-Noncommercial-No Derivative Works 2.5 India
ISSN: 0975-0967 (Online); 0972-5849 (Print)
Source:IJBT Vol.02(3) [July 2003]

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