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NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Biotechnology (IJBT) >
IJBT Vol.02 [2003] >
IJBT Vol.02(3) [July 2003] >
| Title: | Microbial Transformation of Rifamycin: A Novel Approach to Rifamycin Derivatives |
| Authors: | Jobanputra, A H
Patil, G D
Sayyed, R Z
Chaudhari, A B
Chincholkar, S B |
| Keywords: | Biotransformation
Rifamycin s
Rifamycin oxidase
Curvularia lunata
Monocillium
Humicola |
| Issue Date: | Jul-2003 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Biotransformation
of an ansamycin group of antibiotic, rifamycin B (clinically less active) to a
more potent antibiotic rifamycin S, involves the action of rifamycin oxidase.
The extracellular rifamycin oxidase (RO) from Curvularia lunata offers
ease in the process and increased biotransformation potential and yield.
Extracellular RO from C. lunata deserves a great future since it shows
higher activity and biotransformation potential vis-à-vis intracellular
RO from Monocillium and Humicola. Rifamycin S, especiallyamong
the derivatives, has been of great commercial significance as a key
intermediate for the synthesis of several hundreds of semisynthetic rifamycins.
Besides these, rifamycin S has broad-spectrum activity
against Brucella, Chlamydia, Haemophilus, Helicobacter pylori, Legionella and
Staphylococcus. It has also emerged as an antituberculosis and
antileprosy drug. Chemical conversion of rifamycin B against microbial
transformation has been discussed with special emphasis on biotransforming
systems, characteristics of rifamycin oxidase and factors influencing the
production of rifamycin oxidase and biotransformation of rifamycin B to S. |
| Page(s): | 370-377 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0967 (Online); 0972-5849 (Print) |
| Source: | IJBT Vol.02(3) [July 2003]
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