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NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Biotechnology (IJBT) >
IJBT Vol.02 [2003] >
IJBT Vol.02(2) [April 2003] >
| Title: | Immunostimulation: The Sense in Antisense Technology |
| Authors: | Pandey, Archana
Mishra, Satyendra
Misra, Krishna |
| Keywords: | Antisense
Immunostimulation
Vaccine
Oligonucleotide therapy |
| Issue Date: | Apr-2003 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | The
post-human genomic era has led to the development of therapies, which
specifically target molecular
pathways
responsible for diseases. The original concept of antisense therapy was to
simply turn off gene's activity by
a
short synthetic DNA sequence, having sequence complementary to mRNA and thus
block the production of
undesirable
protein. However, during the last two decades this concept has undergone
miraculous change. Today
antisense
therapy is on crossroads. The observation that oligodeoxynucleotides containing
CpG dinucleotides (CpG
DNA)
exhibit immunostimulatory effect has lead to their use as therapeutic agents
and adjuvants for various
diseases.
Knowledge gained from studies of the medicinal chemistry of CpG DNA has
provided a base for designing
the
second generation of CpG DNA agents with immunostimulatory activity. The
present article reviews the recent
developments,
which have caused the revival of antisense therapy. |
| Page(s): | 175-183 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0967 (Online); 0972-5849 (Print) |
| Source: | IJBT Vol.02(2) [April 2003]
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