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|Title:||Bioinformatics: Advancing Biotechnology through Information Technology Part II: In silico Gene Prediction|
|Keywords:||Homology;Ab initio;Synteny;EST;Genome annotation|
|Abstract:||The paper reviews computational tools and algorithms for in silico genome annotation and, in particular, the Bioinformatics resources available for in silico gene prediction. Gene prediction requires a combination of algorithms with different types of biological databases and the author intends to provide the biologist or biotechnology researcher an insight into the use of these methods. The explosion of information seen in molecular biology has created a veritable maze, through which careful navigation is required for research and innovation in biotechnology. Online databases have given scientists and researchers across the world access to unimaginable volumes of biologically relevant data. Bioinformatics, a truly multidisciplinary science, aims to bring the benefits of computer technologies to bear in understanding the biology of life itself. In this second paper of a three part series, the tremendous value of gene prediction algorithms is discussed, in the context of transforming raw biological sequence data into biologically useful knowledge. It is the first step in harnessing the biological data arising out of the genome projects into a new and improved understanding of biology of organisms.|
|ISSN:||0975-0967 (Online); 0972-5849 (Print)|
|Appears in Collections:||IJBT Vol.02(2) [April 2003]|
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