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Indian Journal of Chemistry -Section A (IJC-A) >
IJC-A Vol.50A [2011] >
IJC-A Vol.50A(03-04) [March-April 2011] >
| Title: | Cobalt hexamine trichloride induced toroidal condensation of FtsZ |
| Authors: | Kuchibhatla, Anuradha
Bellare, Jayesh
Panda, Dulal |
| Keywords: | Bioinorganic chemistry
Toroidal condensation
Polymer assembly
Morphology
Polyamines
Inorganic polyamines
Cobalt hexamine trichloride
FtsZ
Z-ring |
| Issue Date: | Mar-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | The bacterial cell division protein, FtsZ,
polymerizes to form a cytokinetic Z-ring at the midcell, which engineers
bacterial cell division. Herein, we have examined the effects of an inorganic
polyamine, cobalt hexamine trichloride, on the assembly of FtsZ in vitro. Cobalt hexamine trichloride strongly
enhances FtsZ assembly, suppresses its GTPase activity and stabilizes FtsZ
polymers. However, CoCl2 and MnCl2 have no detectable
effect on the assembly of FtsZ in vitro.
Interestingly, FtsZ is found to assemble into toroidal structures in the
presence of low concentrations of cobalt hexamine trichloride. The Z-ring in
bacterial cells appears to be a toroidal-like structure, suggesting that the
use of cobalt hexamine trichloride may help to understand the assembly of FtsZ
into toroidal structure. The toroidal structures may also serve as templates to
build toroidal resonators for electrical and thermal applications. |
| Page(s): | 491-497 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0975(Online); 0376-4710(Print) |
| Source: | IJC-A Vol.50A(03-04) [March-April 2011]
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