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Indian Journal of Chemistry -Section A (IJC-A) >
IJC-A Vol.50A [2011] >
IJC-A Vol.50A(03-04) [March-April 2011] >
| Title: | Synthesis, structure and anticancer activity of copper(II) complexes of N-benzyl-2-(diethylamino)acetamide and 2-(diethylamino)-N-phenylethylacetamide |
| Authors: | Singh, Amit P
Kaushik, Nagendra K
Verma, Akhilesh K
Gupta, Rajeev |
| Keywords: | Bioinorganic chemistry
Copper
Amide-based ligands
Anti-cancer activity
Cytotoxicity |
| Issue Date: | Mar-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | The ligands N-benzyl-2-(diethylamino)acetamide, (HL1) and 2-(diethylamino)-N-phenylethylacetamide
(HL2), have
been used to synthesize copper(II) complexes, [Cu(HL1)2](ClO4)2 (1) and
[Cu(HL2)2](ClO4)2
(2), respectively. Both complexes are well characterized by
various spectral and physical methods. The crystal structure of complex (1) reveals that two bidentate ligands
coordinate the Cu(II) ion via Oamide and Namine atoms in
the basal plane whereas one of the ClO4- ions occupies
the apical position maintaining a square–pyramidal geometry. Screening results for anti–proliferative
studies against the U87 and HeLa cancerous cells indicate promising activity.
The complexes enhanced growth inhibition and cell death in a concentration and
time dependent manner for both U87 and HeLa cell lines. Of the two compounds,
complex (2) exhibits better activity against both HeLa and U87 cells.
Further, both complexes are specifically potent against U87 after
72 h of treatment. Micronucleus and apoptosis frequencies are 3 – 4
times higher in treated cells when compared with untreated control. Despite potent in vitro activity, both complexes exhibit diminished cytotoxicity
against the normal human HEK cells at all effective concentrations. |
| Page(s): | 474-483 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0975(Online); 0376-4710(Print) |
| Source: | IJC-A Vol.50A(03-04) [March-April 2011]
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