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IJC-A Vol.50A(03-04) [March-April 2011] >

Title: Effect of -lactamase-catalyzed hydrolysis of cephalosporins on peroxynitrite-mediated nitration of serum albumin and cytochrome c
Authors: Jakka, Surendar Reddy
Mugesh, Govindasamy
Keywords: Bioinorganic chemistry
Enzyme hydrolysis
Protein nitration
Issue Date: Mar-2011
Publisher: NISCAIR-CSIR, India
Abstract: The hydrolysis of -lactam antibiotics by -lactamases is one of the major bacterial defense systems. These enzymes generally hydrolyze a variety of antibiotics including the latest generation of cephalosporins, cephamycins and imipenem. In this paper, the effect of cephalosporins-based antibiotics on the peroxynitrite-mediated nitration of protein tyrosine is described. Although some of the antibiotics have weak inhibitory effect on the nitration reactions in the absence of -lactamase, they exhibit very strong inhibition in the presence of -lactamase. This is due to the elimination of heterocyclic thiol/thione moieties from cephalosporins by -lactamase-mediated hydrolysis. After the elimination, the thiols/thiones effectively scavenge peroxynitrite, leading to the inhibition of the nitration reactions.
Page(s): 447-452
CC License:  CC Attribution-Noncommercial-No Derivative Works 2.5 India
ISSN: 0975-0975(Online); 0376-4710(Print)
Source:IJC-A Vol.50A(03-04) [March-April 2011]

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