NISCAIR Online Periodicals Repository

NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR)  >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Chemistry -Section A (IJC-A) >
IJC-A Vol.50A [2011] >
IJC-A Vol.50A(03-04) [March-April 2011] >


Title: Substrate orientation and the origin of catalytic power in xanthine oxidoreductase
Authors: Cao, Hongnan
Pauff, James
Hille, Russ
Keywords: Bioinorganic chemistry
Catalysis
Reaction mechanisms
Molybdenum enzymes
Xanthine oxidoreductase
Issue Date: Mar-2011
Publisher: NISCAIR-CSIR, India
Abstract: With the chemical course of the reaction catalyzed by the molybdenum-containing hydroxylase xanthine oxidoreductase now relatively well-understood, efforts in the field have now turned to understanding the catalytic power of the enzyme in the context of its structure. The present minireview is an account of recent efforts, from the authors’ laboratory and elsewhere, towards understanding the role of active site amino acid residues in accelerating reaction rate. On the basis of recent site-directed mutagenesis work, in conjunction with protein X-ray crystallography, it is now possible to attribute the specific extent to which each contributes to transition state stabilization and the means by which this occurs.
Page(s): 355-362
CC License:  CC Attribution-Noncommercial-No Derivative Works 2.5 India
ISSN: 0975-0975(Online); 0376-4710(Print)
Source:IJC-A Vol.50A(03-04) [March-April 2011]

Files in This Item:

File Description SizeFormat
IJCA 50A(03-04) 355-362.pdf936.99 kBAdobe PDFView/Open
 Current Page Visits: 822 
Recommend this item

 

National Knowledge Resources Consortium |  NISCAIR Website |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2012 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 575133 since 06-Feb-2009  Last updated on 26-Aug-2014Webmaster: nopr@niscair.res.in