26-May-2013
06:33:16 IST
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NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.50B [2011] >
IJC-B Vol.50B(03) [March 2011] >
| Title: | Synthesis and biological evaluation of pyrido(2, 3-d)pyrimidine-carboxylate derivatives |
| Authors: | Shanmugasundaram, P
Harikrishnan, N
Aanandini, M Vijey
Kumar, M Sathish
Sateesh, J N |
| Keywords: | Pyrido(2,3-d)pyrimidnes
CS2
Amidines
4-haloanilines
Malonic acid
Antibacterial
Antifungal
Antitumor activity |
| Issue Date: | Mar-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Ethyl-5-amino-8-(4-halophenyl)-2-methyl-4,7-dioxo-3,4,5,6,7,8-hexahydro
pyrido(2,3-d)
pyrimidine-6-carboxylate and ethyl-5-amino-8-(4-halophenyl)-2-amino-4,7
dioxo-3,4,5,6,7,8 hexahydropyrido(2,3-d)pyrimidine-6-carboxylate
derivatives have been synthesized through nucleophilic substitution reactions
with the use of amidines, followed by 4-haloanilines and malonic acid. These
synthesized novel derivatives have been confirmed by elemental analysis, IR, 1H
NMR and mass spectra. These novel derivatives have also been screened for
antibacterial, antifungal and antitumor activity. |
| Page(s): | 284-289 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.50B(03) [March 2011]
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