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Title: Synthesis and biological evaluation of pyrido(2, 3-d)pyrimidine-carboxylate derivatives
Authors: Shanmugasundaram, P
Harikrishnan, N
Aanandini, M Vijey
Kumar, M Sathish
Sateesh, J N
Keywords: Pyrido(2,3-d)pyrimidnes
Malonic acid
Antitumor activity
Issue Date: Mar-2011
Publisher: NISCAIR-CSIR, India
Abstract: Ethyl-5-amino-8-(4-halophenyl)-2-methyl-4,7-dioxo-3,4,5,6,7,8-hexahydro pyrido(2,3-d) pyrimidine-6-carboxylate and ethyl-5-amino-8-(4-halophenyl)-2-amino-4,7 dioxo-3,4,5,6,7,8 hexahydropyrido(2,3-d)pyrimidine-6-carboxylate derivatives have been synthesized through nucleophilic substitution reactions with the use of amidines, followed by 4-haloanilines and malonic acid. These synthesized novel derivatives have been confirmed by elemental analysis, IR, 1H NMR and mass spectra. These novel derivatives have also been screened for antibacterial, antifungal and antitumor activity.
Description: 284-289
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.50B(03) [March 2011]

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