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Title: Synthesis and biological evaluation of pyrido(2, 3-<i style="">d</i>)pyrimidine-carboxylate derivatives
Authors: Shanmugasundaram, P
Harikrishnan, N
Aanandini, M Vijey
Kumar, M Sathish
Sateesh, J N
Keywords: Pyrido(2,3-<i style="">d</i>)pyrimidnes
Malonic acid
Antitumor activity
Issue Date: Mar-2011
Publisher: NISCAIR-CSIR, India
Abstract: Ethyl-5-amino-8-(4-halophenyl)-2-methyl-4,7-dioxo-3,4,5,6,7,8-hexahydro pyrido(2,3-<i style="">d</i>) pyrimidine-6-carboxylate and ethyl-5-amino-8-(4-halophenyl)-2-amino-4,7 dioxo-3,4,5,6,7,8 hexahydropyrido(2,3-<i style="">d</i>)pyrimidine-6-carboxylate derivatives have been synthesized through nucleophilic substitution reactions with the use of amidines, followed by 4-haloanilines and malonic acid. These synthesized novel derivatives have been confirmed by elemental analysis, IR, <sup>1</sup>H NMR and mass spectra. These novel derivatives have also been screened for antibacterial, antifungal and antitumor activity.
Description: 284-289
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.50B(03) [March 2011]

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